Is benzocaine soluble in water?

Benzocaine occurs in two forms: a crystalline salt (benzocaine HCl) that is soluble in water at 0.4 g/L, and a nonwater-soluble basic form that must be dissolved in ethyl alcohol at a concentration of 0.2 g/ml before it is sufficiently soluble in water to create a functional induction dose.

Why is benzocaine not soluble in water?

Benzocaine is a unique local anesthetic because it does notcontain a tertiary amine. The pKa of the aromatic amine is 3.5ensuring that benzocaine is uncharged at physiological pH. Because it is uncharged, it is not water soluble but is ideal fortopical applications.

How do you dissolve benzocaine?

Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol… So it won’t do much in water, would dissolve better in vinegar, and pretty well in everclear or vodka.

What solvents is benzocaine soluble in?

The mole fraction solubility of benzocaine decreases in the order: 1,4-dioxane, acetone, ethyl acetate, chloroform, acetonitrile, methanol, n-butanol and toluene.

What is the solubility of benzocaine in water g ml?

Benzocaine is a surface anesthetic that reversibly inactivates voltage-dependent sodium channels. Solubility : Soluble in water (0.4 mg/ml at 20° C), methanol, chloroform (500 mg/ml), ethanol (50 mg/ml), and ether (250 mg/ml).

Is it illegal to have benzocaine?

Although benzocaine is a legal substance, it is illegal to supply it to the underground drugs trade. … But drug dealers like to use it in powder form to dilute pure class A and class B drugs such as naphyrone and mephedrone because of the numbing sensation it offers when placed on the skin.

Is benzocaine a weak acid or base?

Benzocaine is a weak base with a pKb of 11.5, and pentobarbital is a weak acid with a pKa of 8.1.

What is the MP of benzocaine?

The melting point of benzocaine is 88–90 °C, and the boiling point is about 310 °C. The density of benzocaine is 1.17 g/cm3.

Is Benzonatate the same as benzocaine?

Benzonatate is a medication taken orally to suppress coughs. It has an anesthetic (numbing) action similar to that of benzocaine and numbs the stretch sensors in the lungs. It is the stretching of these sensors with breathing that causes the cough.

What’s better benzocaine or lidocaine?

Lidocaine and benzocaine were equally efficient, and both were better than placebo in reducing pain caused by insertion of needles into the palate.

What are the side effects of benzocaine?

Side Effects

Is benzocaine toxic to dogs?

Being a local anesthetic, benzocaine will numb the throat when swallowed, or the mouth if chewed. This can pose a risk for aspiration and may become a choking hazard, particularly in those pets that may be more susceptible to aspiration.

What is the conjugate acid of benzocaine?

(2) Look up the structures and melting points of the three compounds you will be separating in the second part. The pKa of benzoic acid is 4.2; the pKa of the conjugate acid of benzocaine is 2.5.

How do you synthesis benzocaine?

A three-step synthesis is used to create benzocaine. First p- aminobenzoic acid is produced from taking p-acetotoluidide and oxidizing it with magnesium sulfate. Then to create an amino acid, p-aminobenzoic acid is then heated with hydrochloric acid.

What is the effect of the 95% ethanol on the solubility of benzocaine?

Benzocaine is prepared by the Fischer esterification of 4-aminobenzoic acid with ethanol. The reaction is a chemical equilibrium. Per Le Châtelier’s Principle, any water in the mixture will shift the position of equilibrium to the left. Using 95 % ethanol-5 % water will decrease the yield of benzocaine.

Is benzocaine a drug?

Benzocaine is a topical anesthetic contained in some marketed over-the-counter (OTC) oral drug products intended to relieve pain from a variety of conditions such as sore throats, canker sores, and irritation of the mouth and gums.

What is the RF value of benzocaine?

.35 Additionally, the known IR data for Benzocaine looks very similar to the IR spectrum obtained in the experiment. TLC spotting of the crude solid and the starting material (PABA) was done, as well as a co-spot of both. Results showed an RF value of .35 for the crude product, and RF value of .

Can you get high of benzocaine?

Some people may also smoke or snort benzocaine by itself trying to replicate a cocaine high. However, benzocaine is far from a safer high. Because its effects are much weaker, people may use it in higher doses, which can lead to a fast or slow heartbeat, stopped breathing, or seizures.

What is benzocaine 20%?

Benzocaine is used short term to relieve pain from minor mouth problems (such as toothache, canker sores, sore gums/throat, mouth/gum injury). It is a local anesthetic that works by numbing the painful area.Do not use this product for children younger than 2 years due to risk of serious side effects.

Is benzocaine supposed to burn?

Contact dermatitis and/or hypersensitivity to benzocaine can cause burning, stinging, pruritus, tenderness, erythema, rash, urticaria and edema. Rarely, benzocaine may induce methemoglobinemia causing respiratory distress and cyanosis.

What happens if you use too much benzocaine?

An overdose of benzocaine topical applied to the skin can cause life-threatening side effects such as uneven heartbeats, seizure (convulsions), coma, slowed breathing, or respiratory failure (breathing stops). Avoid eating within 1 hour after using benzocaine topical on your gums or inside your mouth.

Can benzocaine cause positive drug test?

In turn, the misapprehension is created that commonly used dental anesthetics such as benzocaine may yield false positives in urine drug testing, indicating illicit use of cocaine.

How do you take benzocaine?

To treat minor skin conditions, apply a thin layer of benzocaine topical to the affected area. If using the spray, hold the container 6 to 12 inches away from the skin. Do not spray this medication onto your face. Spray it instead on your hands and then rub it onto the face, avoiding contact with your eyes.

What does biphenyl smell like?

pleasant Biphenyl is insoluble in water, but soluble in typical organic solvents. The biphenyl molecule consists of two connected phenyl rings. … Biphenyl.

Names
Appearance Colorless to pale-yellow crystals
Odor pleasant
Density 1.04 g/cm3
Melting point 69.2 °C (156.6 °F; 342.3 K)

What color is benzocaine?

About 0.05 g yields the reaction described for the identification of primary aromatic amines under 2.1 General identification tests, producing an orange-red precipitate. Melting range. 88-92°C.

What is the Iupac name for benzocaine?

C9H11NO2 Benzocaine | C9H11NO2 – PubChem.

Is benzonatate better than cough syrup?

Tessalon Perles (benzonatate) can help relieve a dry cough, but it is not the best treatment if you’re coughing up mucus. Breaks up mucus and relieves cough. Mucinex Dm (Dextromethorphan / Guaifenesin) is okay for loosening congestion in your chest and throat, but it could prevent you from coughing the mucus up.

Who should not take benzonatate?

You should not use this medicine if you are allergic to benzonatate or topical numbing medicines such as tetracaine or procaine (found in some insect bite and sunburn creams). Tell your doctor if you are pregnant or breastfeeding. Benzonatate is not approved for use by anyone younger than 10 years old.

Is benzonatate good for dry cough?

Benzonatate (Tessalon) can help relieve a dry cough. It works within 15 to 20 minutes and can last up to 8 hours. The medication has little to no side effects in most people, but it’s not safe for young children to take.