Decorin has been shown to either enhance or inhibit the activity of TGF-beta 1. The primary function of decorin involves regulation during the cell cycle. It has been involved in the regulation of autophagy, of endothelial cell and inhibits angiogenesis.
Is Perlecan a glycoprotein?
Heparan sulfate proteoglycans are glycoproteins with one or more heparan sulfate chains, which are a type of glycosaminoglycan (GAG) chain (Domogatskaya et al., 2012). The heparan sulfate proteoglycans present in the basement membrane are perlecan, agrin, and collagen XVIII.
Is biglycan a proteoglycan?
Biglycan, also known as PG-I and PG-S, is another small proteoglycan present in both cartilage and bone [164, 165]. Biglycan is highly homologous to decorin.
What is BGN gene?
BGN (Biglycan) is a Protein Coding gene. Diseases associated with BGN include Spondyloepimetaphyseal Dysplasia, X-Linked and Meester-Loeys Syndrome. Among its related pathways are Articular Cartilage Extracellular Matrix and Chondroitin sulfate/dermatan sulfate metabolism.
Is Aggrecan a gag?
Almost 90% of aggrecan mass is comprised of substituted GAG chains which are mostly chondroitin sulfate chains, but also include keratan sulfate chains with N- and O-linked oligosaccharides.
What is the function of fibrillin?
Fibrillin is a glycoprotein, which is essential for the formation of elastic fibers found in connective tissue. Fibrillin is secreted into the extracellular matrix by fibroblasts and becomes incorporated into the insoluble microfibrils, which appear to provide a scaffold for deposition of elastin.
Where is Perlecan found?
Specifically, it is found in part of the extracellular matrix called the basement membrane, which is a thin, sheet-like structure that separates and supports cells in many tissues. Perlecan is also found in cartilage, a tough, flexible tissue that makes up much of the skeleton during early development.
Where is Perlecan expressed?
As perlecan is expressed in both vascular and avascular tissues, it follows that this proteoglycan is directly involved in a variety of cellular events including cell adhesion [10,11], thrombosis [21], and vascular development [34].
Is Perlecan a proteoglycan?
Perlecan is a large multidomain (five domains, labeled I-V) proteoglycan that binds to and cross-links many extracellular matrix (ECM) components and cell-surface molecules. Perlecan is synthesized by both vascular endothelial and smooth muscle cells and deposited in the extracellular matrix.
What is wireless mode 802.11 BGN?
802.11g. … 802.11g attempts to combine the best of both 802.11a and 802.11b. 802.11g supports bandwidth up to 54 Mbps, and it uses the 2.4 GHz frequency for greater range. 802.11g is backward compatible with 802.11b, meaning that 802.11g access points will work with 802.11b wireless network adapters and vice versa.
What are Chondrogenic cells?
Chondroblasts are progenitor cells that secrete the extracellular matrix (ECM), while chondrocytes are involved in nutrient diffusion and matrix repair. Both cell types are required to form cartilage.
Is Aggrecan found in bone?
Aggrecan is the major structural macromolecule of cartilage, which contributes to water retention and provides resistance to compression. Whereas cartilage is localized on the joint surface and help movement of individuals, it serves as a primodium of most bones during development.
What is Lubricin and what is its function in the knee joint?
Lubricin is a surface-active mucinous glycoprotein secreted in the synovial joint that plays an important role in cartilage integrity. In healthy joints, lubricin molecules coat the cartilage surface, providing boundary lubrication and preventing cell and protein adhesion.
What are the two main functions of fibrillin?
Fibrillin-1 and fibrillin-2 are large cysteine-rich glycoproteins that serve two key physiological functions: as supporting structures that impart tissue integrity and as regulators of signaling events that instruct cell performance.
What is fibrillin made of?
A major fibrillar component is a glycoprotein called fibrillin. The structure of fibrillin consists of several cysteine-rich motifs and exhibits a multidomain organization similar to epidermal growth factor. The structure is stabilized by disulfide linkages.
Is fibrillin a protein?
Fibrillin-1 is a 350 kDa calcium-binding protein which assembles to form 10-12 nm microfibrils in the extracellular matrix (ECM).
Where is basement membrane?
The basement membrane is a thin, pliable sheet-like type of extracellular matrix, that provides cell and tissue support and acts as a platform for complex signalling. The basement membrane sits between epithelial tissues including mesothelium and endothelium, and the underlying connective tissue.
What is a basal lamina?
Basal lamina are extracellular structures found closely apposed to the plasma membrane on the basal surface of epithelial and endothelial cells and surround muscle and fat tissues.
Where is fibronectin found?
extracellular matrix Fibronectin is located in the extracellular matrix of embryonic and adult tissues (not in the basement membranes of the adult tissues), but may be more widely distributed in inflammatory lesions.
Where is agrin produced?
Development of the neuromuscular junction (NMJ) requires secretion of specific isoforms of the proteoglycan agrin by motor neurons. Secreted agrin is widely expressed in the basal lamina of various tissues, whereas a transmembrane form is highly expressed in the brain.
Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with Sun’Agri and INRAE in Avignon between 2019 and 2022. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. I love to write and share science related Stuff Here on my Website. I am currently continuing at Sun’Agri as an R&D engineer.