How does Y-90 decay?

Y-90 decays by beta minus emission, mainly to the Zr-90 ground state, with a small branch to the level at 1760 keV.

What is the Y-90 procedure?

Radioembolization is a minimally invasive procedure that combines embolization and radiation therapy to treat liver cancer. Tiny glass or resin beads filled with the radioactive isotope yttrium Y-90 are placed inside the blood vessels that feed a tumor.

Is Y-90 a beta emitter?

Yittrium-90 is a pure beta-emitter, with a decay energy of 0.94 MeV and the average penetration depth in human tissue is 2.4 mm. In the form of microspheres, it is suitable for selective arterial injection. The physical half-life of Y-90 is 64.2 h.

Is yttrium 90 an isotope?

Radioactive isotope of yttrium. A beta/gamma-emitter with a half life of 2.7 days. Yttrium 90 has been investigated for the treatment of Colon Cancer and Colorectal Cancer.

How long does Y90 procedure take?

If there are multiple tumors, the procedure may need to be repeated in another blood vessel. The procedure takes about one hour to complete.

Is the Y90 palliative?

Y-90 radioembolisation is a palliative treatment for primary liver lesions and liver metastatic disease which uses ionising radiation to shrink tumours. It is generally used to relieve the symptoms of liver tumours rather than to cure the underlying condition.

How many times can you get Y-90?

Patients are typically limited to two treatments, although doctors can take another approach — only with concentrated chemotherapy and larger particles — once radiation limits are reached. “He could potentially have that multiple times to prolong his survival and keep him doing well,” Dr. McBride says.

Are you radioactive after Y-90 treatment?

The Y90 has a half-life of 64.2 hours. This means that it will be non-radioactive in about a month’s time.

What are the side effects of Y-90?

The most common side effect after Y-90 radiotherapy is fatigue. This can be mild or severe. It can last up to a few weeks. Other side effects include: • Poor appetite • Mild abdominal pain • Slight fever • Nausea These symptoms should slowly go away over 1 to 2 weeks.

What type of radiation is Y90?

Y90 is a pure beta-particle-emitter with a physical half-life of 64.2 hours, 0.94 MeV decay energy, and an average penetrative depth of 2.4mm in human tissue.

What is strontium-90 half-life?

29 years Strontium-90 has a half- life of 29 years and emits beta particles of relatively low energy as it decays. Yttrium-90, its decay product, has a shorter half-life (64 hours) than strontium-90, but it emits beta particles of higher energy.

How is strontium 89 produced?

) is a radioactive isotope of strontium produced by nuclear fission, with a half-life of 50.57 days. It undergoes β− decay into yttrium-89.

What is a Y90 mapping?

Step 1: Mapping: The first step in treatment with Y-90 Radiotherapy is a called a mapping angiogram. The mapping procedure will take about 2-4 hours. Dr. Christenson will place a small plastic tube (called a catheter) into one of the vessels in your groin and direct the catheter to the blood vessels in your liver.

What is the difference between TACE and Y90?

Y90 is better tolerated with a smaller side effect profile when compared to TACE therapy. However, Y90 is an expensive treatment option, which isn’t feasible for certain patient populations, such as those on Medicaid. Y90 is a very well-tolerated procedure.

What is the element of Y?

Y is the symbol for the element yttrium.

What happens after a Y90 procedure?

You may feel more tired than usual and tire more easily for up to 3 weeks after the procedure. You may feel sick to your stomach and not feel like eating for several days. You will be given a prescription for medicine to control the nausea. You may lose some weight before you feel like eating again.

Does Y90 require general anesthesia?

You will still feel sleepy for a while after the procedure. For some people, using moderate sedation is not safe. If this is true for you, you will need general anesthesia (medicine to make you sleep during the procedure).

How much does Y90 treatment cost?

Cost of the procedures and hospital admission was obtained from the hospital chargemaster. The primary outcome was the overall difference in cost between Y-90 vs TACE for treatment of hepatocellular carcinoma at Einstein Medical Center. The price of a Y-90 ranges from $30,000 to $35,000 with an average of $32,500.

Is y90 FDA approved?

The FDA has approved TheraSphere™ Yttrium-90 Glass Microspheres for the treatment of patients with hepatocellular carcinoma. The FDA has approved TheraSphere™ Yttrium-90 (Y-90) Glass Microspheres for the treatment of patients with hepatocellular carcinoma.

Is liver embolization painful?

The area where the catheter was put through your skin into your artery (the puncture site) may be sore for a day or two after the procedure. You will probably have a bruise for at least a week. You may feel like you have influenza (flu) and may feel tired and have a low fever and an upset stomach.

What is Liver mapping?

Radioembolization is used to treat primary liver cancer and other cancers that have metastasized to the liver. The preparatory angiogram is performed to map out the veins and arteries of the liver and block those that leave the liver and go to other organs.

What are chemo beads?

Microspheres, or beads, combined with cancer-killing chemotherapeutic agents are delivered to the blood vessel feeding the tumor. While the chemo attacks the cancer, the microspheres get stuck in the vessels and choke off the blood supply to the tumor — a process called embolization.

Where is brachytherapy done?

Placement may be inside a body cavity or in body tissue: Radiation placed inside a body cavity. During intracavity brachytherapy, a device containing radioactive material is placed in a body opening, such as the windpipe or the vagina. The device may be a tube or cylinder made to fit the specific body opening.

How effective is SIRT treatment?

In recent studies, SIRT was most effective in minimizing the risk of tumour progression in the treated lobe and had more of an effect on total liver volume, making it a more suitable modality for selected patients with substantial unilateral disease burden.

What are the side effects of Radioembolization?

Side effects of radioembolization are mild, and commonly include:

What is microwave tumor ablation?

Microwave ablation (MWA) is a minimally-invasive treatment for cancer. MWA uses ultrasound, computed tomography (CT), or magnetic resonance imaging (MRI) to guide placement of a needle-like probe into a tumor. MWA uses microwaves to heat and destroy the tumor. Doctors use MWA for the same indications as RFA.

What are the benefits of yttrium-90?

Benefits of Yttrium-90 Therapy Painless for most people. Safe and well-tolerated.Able to deliver a higher radiation dose than external radiation therapy or radiation given outside the body. Helpful in preserving healthy tissue, as the radiation releases close to the tumor.

What is the TACE procedure?

Trans-arterial chemoembolization (TACE) It combines embolization with chemotherapy (chemo). Most often, this is done by giving chemotherapy through the catheter directly into the artery, then plugging up the artery, so the chemo can stay close to the tumor.