Aminophylline is available as tablets intended for oral administration, containing 100 mg or 200 mg of Aminophylline, USP (calculated as the dihydrate) per tablet (equivalent to 79 mg or 158 mg of theophylline anhydrous).
Why aminophylline is not recommended?
Intravenous aminophylline is not recommended for acute exacerbations. Theophylline is a relatively poor bronchodilator, as adverse effects limit the dose and make it less effective than inhaled bronchodilators.
Why is theophylline when administered intravenously is given as aminophylline?
Aminophylline is indicated for control of reversible airway constriction, to prevent bronchoconstriction, and as an adjunct with other respiratory disease treatment. The uses are similar to the indications for theophylline because it is a salt form of theophylline.
Which therapeutic use is associated with the drug aminophylline theophylline?
Aminophylline is used to prevent and treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema, and other lung diseases.
Does aminophylline increase heart rate?
Aminophylline competitively antagonizes the cardiac actions of adenosine at the cell surface receptors. Thus, it increases heart rate and contractility.
How is clearance of theophylline calculated?
- Calculate Clearance (CL) CL = (Daily Dose/24) / Cpss. where: Daily dose = mg/day of theophylline. Cpss = steady state level (mg/l)
- Calculate Incremental Loading Dose (ILD) OR Temporary Interruption (TI) -Same as above.
- Determine new infusion rate (ko’) -Same as above.
Why is theophylline no longer used for asthma?
For maintenance therapy of asthma, theophylline may be obsolete because it is merely a relatively weak bronchodilator that adds little but side effects to dose- optimized inhaled ~2-agents … and does not address the underlying inflammation, a fundamental charac- teristic of the disease.
When a patient is receiving aminophylline the nurse should observe for?
[26] Patients who receive aminophylline must be monitored for serum concentrations of the drug to ensure they are within therapeutic serum concentrations. There is no specific antidote to reverse toxicity, so it is vital to avoid taking high doses without approval from the clinician.
Is aminophylline and theophylline same?
Aminophylline is the ethylenediamine salt of theophylline. Theophylline stimulates the CNS, skeletal muscles, and cardiac muscle. It relaxes certain smooth muscles in the bronchi, produces diuresis, and causes an increase in gastric secretion. Aminophylline is the ethylenediamine salt of theophylline.
Why is IV aminophylline given slowly?
Intravenous Aminophylline must be administered very slowly to prevent dangerous central nervous system and cardiovascular side-effects due to direct stimulating effect of Aminophylline.
How is aminophylline diluted?
Aminophylline (dihydrate) is approximately 79% of anhydrous theophylline by weight. Aminophylline Injection is administered by slow intravenous injection or diluted and administered by intravenous infusion.
Can aminophylline be given IM?
This suggests that, although usually not recommended, self-administration of a single dose of aminophylline by i.m. route may temporarily help theophylline-responsive patients in distress, when other routes of administration are not available and facilities for intensive conventional treatment are lacking.
How do you take aminophylline injection?
Aminophylline Injection B.P. 250mg/10ml is for slow intravenous administration. The solution may be injected very slowly, or it may be infused in a small volume of either 5% dextrose or 0.9% sodium chloride injection. Aminophylline should not be administered concomitantly with other xanthine drugs.
How long does it take theophylline to work?
Regular use of this medication does not cause it to lose its effect or make you more dependent on it. This medication may be used alone or with an inhaled bronchodilator. How fast does this medication work? This medication works within 30 minutes.
What is aminophylline used to treat?
Aminophylline is a bronchodilator that is used with other medications to treat sudden worsening of the symptoms of asthma, bronchitis, or emphysema.
Does aminophylline lower BP?
When both active treatments were combined, the effect on total electromechanical systole, corrected for heart rate, was potentiated (mean decrease -23.3 msec; range -19.1 to -33.1). Neither aminophylline nor the combination affected heart rate or blood pressure, suggesting no increase in myocardial oxygen consumption.
What happens when aminophylline is exposed to air?
Upon exposure to air Aminophylline gradually loses ethylenediamine and absorbs carbon dioxide with the liberation of free theophylline. Even in the absence of light, Aminophylline is gradually degraded on exposure to a humid atmosphere, the decomposition being faster at higher temperatures. Definition.
Can aminophylline cause hypotension?
Both compounds produced a dose-dependent hypotension. Aminophylline frequently caused bradycardia in intact dogs and positive chrono- and inotropic effects in isolated atria.
What is aminophylline cream?
Aminophylline, an approved prescription drug used in the treatment of asthma, is an ingredient used in many of these thigh cream products that marketers claim will dissolve the fat and smooth the skin.
What happens if aminophylline is infused too rapidly?
Too rapid intravenous administration may result in the following symptoms: anxiety, headache, nausea and vomiting, severe hypotension, dizziness, faintness, lightheadedness, palpitations, syncope, precordial pain, flushing, profound bradycardia, premature ventricular contractions, cardiac arrest.
What class is aminophylline?
Aminophylline belongs to a group of medicines known as bronchodilators. Bronchodilators are medicines that relax the muscles in the bronchial tubes (air passages) of the lungs. They relieve cough, wheezing, shortness of breath, and troubled breathing by increasing the flow of air through the bronchial tubes.
How does aminophylline help asthma?
Aminophylline is a complex of theophylline and ethylenediamine. Its main pharmacological action is relaxation of bronchial smooth muscle. Two meta-analyses examining the efficacy of aminophylline in acute asthma attacks in children and in adults have been reported by the Cochrane Collaboration.
Why is aminophylline used in asthma?
Aminophylline is a methylxanthine bronchodilator composed of theophylline and ethylenediamine. Theophylline relaxes the smooth muscle of the bronchial airways and pulmonary blood vessels as well as reducing airway responsiveness to histamine, methacholine, adenosine and other chemical mediators.
Is theophylline an inhaler?
If sudden shortness of breath occurs, use your quick-relief inhaler as prescribed. Theophylline is available under the following different brand names: Theo 24, Theochron, Elixophyllin, aminophylline, and Uniphyl.
What is the difference between salbutamol and aminophylline?
The results show that intravenous aminophylline is superior to intravenous salbutamol in the doses given in the initial treatment of acute asthma and that the combination when given intravenously is not better than aminophylline alone.
What are contraindications of theophylline?
Who should not take THEOPHYLLINE?
- overactive thyroid gland.
- a condition with low thyroid hormone levels.
- diabetes.
- cystic fibrosis.
- alcoholism.
- high blood pressure.
- a heart attack.
- angina, a type of chest pain.
Why would adenosine be ineffective in persons taking theophylline?
Some of the side-effects of theophylline (central stimulation, gastric secretion, diuresis and arrhythmias) may be due to adenosine receptor antagonism (A1A receptors) and these may therefore be avoided by PDE inhibitors or by doxifylline when it is available, as discussed above.
Is Acebrophylline a bronchodilator?
Acebrophylline (Ambroxol + Theophylline-7-Acetate), another Xanthine derivative, is used as a bronchodilator for the treatment of bronchial asthma and COPD in adults.
Is aminophylline being discontinued?
Aminophylline (Phyllocontin®) modified release tablets are being discontinued in both the 225mg and 350mg strengths. Remaining supplies in the distribution chain are expected to be exhausted by early April 2021.
What is another name for aminophylline?
What brand names are available for aminophylline? Norphyl, Phyllocontin, Truphylline.
Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with Sun’Agri and INRAE in Avignon between 2019 and 2022. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. I love to write and share science related Stuff Here on my Website. I am currently continuing at Sun’Agri as an R&D engineer.