What are a J mice?

The A/J strain is an inbred albino strain of mouse model. It is very frequently used in cancer research, on account of its strong tendency to develop tumors when presented with common carcinogens. It is one of the most popular strains used in mouse experiments.

What is an outbred mice?

Outbred mice are called stocks, which are defined as a closed population (for at least four generations) of genetically variable mice that are bred to maintain maximal heterozygosity.

What is SJL J mice?

The SJL/J mice is most well known for its very high rate of developing reticulum cell sarcoma which resembles Hodgkin’s disease. The tumors are present in 90% of individuals from around one year of age. They appear first in the lymphatic system and spleen, before spreading to the liver and thymus.

What is mechanical mouse?

A mouse that uses a rubber ball that makes contact with wheels inside the unit when it is rolled on a pad or desktop. Contrast with optical mouse.

What is a congenic strain?

A congenic strain is an inbred strain that contains a small genetic region (ideally a single gene) from another strain, but which is otherwise identical to the original inbred strain.

What is the difference between inbred and outbred mice?

Genetically, there are two major classes of laboratory mice: inbred and outbred. Inbred mice are genetically homogeneous and there is very little variation or heterogeneity within a pure inbred strain. … Outbred mice are bred specifically to maximize genetic diversity and heterozygosity within a population.

What is a CD 1 mouse?

CD-1 IGS mice are outbred mice derived from a group of outbred Swiss mice developed at the Anti-Cancer Center in Lausanne, Switzerland. They were imported to the US in 1926 and to Charles River in 1959. The CD-1 IGS mice are generally used for genetics, toxicology, pharmacology, and aging research.

Why use Swiss Webster mice?

Also Known As:SW, Swiss Inbred SWR/J mice are used widely in research as a general purpose strain. Aging mice exhibit a high incidence of lung and mammary gland tumors. They also develop extreme polydipsia and polyuria (nephrogenic diabetes insipidus) with increasing age.

What is the laser mouse?

A laser mouse is a type of optical mouse that uses laser light to detect mouse movement. Like all optical mice, it has no moving parts inside. The laser mouse is more accurate than the standard LED optical mouse, although the latter has gotten much closer over the years.

What is opto mechanical mouse?

Updated: 09/03/2019 by Computer Hope. Alternatively referred to as the ball mouse, the optical-mechanical or optomechanical mouse consists of a ball that rolls one of two wheels inside the mouse. Each wheel contains a circle of holes or notches, allowing an LED light to shine through and be detected by a sensor.

What are the four types of mouse?

What Are the Different Types of Computer Mouse Models?

What are recombinant strains?

A recombinant inbred strain (or recombinant inbred line) is an organism with chromosomes that incorporate an essentially permanent set of recombination events between chromosomes inherited from two or more inbred strains.

What is gene knockout mice?

A knockout mouse is a laboratory mouse in which one or more genes have been turned off or knocked out. To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. Knockout mice are used to study what happens in an organism when a particular gene is absent. …

What is a cross involving only one trait called?

A monohybrid cross is a cross between two organisms with different variations at one genetic locus of interest. The character(s) being studied in a monohybrid cross are governed by two or multiple variations for a single locus.

Why do we use inbred mice?

Inbred strains of mice and rats are invaluable animal resources for studying the genetic bases of phenotypic variation. They have been obtained through brother–sister mating for more than 20 generations, so all individuals have the same genome (isogenic) and each individual is homozygous at each locus.

Does inbreeding affect humans?

Studies have confirmed an increase in several genetic disorders due to inbreeding such as blindness, hearing loss, neonatal diabetes, limb malformations, disorders of sex development, schizophrenia and several others.

What is an example of an inbred rat strain?

Examples of some inbred strains are: ACI, FHH, BN. These are animals in which there is a structural change in the DNA. … These are formed by crossing two inbred strains, followed by 20 or more consecutive generations of brother and sister mating.

What is Swiss albino mice?

Swiss Albino is usually used in toxicology studies. … Swiss being an outbred animal, is suitable for toxicology as it has variability between animals. However, if you take other inbred animals such as BALB/c, C57BL/6, etc, they are very similar and you would not have so much variations between animals.

What does a 3D mouse do?

A 3D mouse is a pointing and control device specialized for movement in virtual 3D (three-dimensional) environments. 3D mouse devices have used a number of different means to control 3D movement as well as 2D pointing, including multi-axis sensors, accelerometers, IR lights and IR sensors.

Is CD 1 a commonly used mouse strain?

Overview. CD1 IGS (also known as Crl:CD1(ICR)) is an albino outbred strain of mouse model that has frequently been used in toxicology and pharmacological research. It is the most popular strain of outbred mouse.

What is Swiss Webster mice?

Swiss Webster (CFW) Mouse Details This stock resulted from the selective inbreeding by Dr. Leslie Webster using foundation animals from a large colony of Swiss mice maintained at Rockefeller Institute following importation from Switzerland in 1926. … Highly inbred at the time they were acquired by Carworth.

Which is the other strain of albino rat?

Wistar rat is another common hybrid albino model animal. … Table 3.

strain CD-1
major features outbred, albino
advantages genetic variability
main applications positional cloning, genotypic selection, toxicology testing (questionable)

Why are white mice used in labs?

Most of the mice and rats used in medical trials are inbred so they are almost identical genetically helping to make the results of medical trials more uniform. Another reason they’re used as models in medical testing is that their genetic, biological and behavior characteristics closely resemble those of humans.