What are asteroid bodies in sporotrichosis?

Abstract. The asteroid body in Sporotrichosis (AB) is a characteristic structure that allows diagnosis in lymphangitic presentations and whose generation and composition is not fully understood. Our study focused on the biological relationship between the yeast and host elements present in the AB.

What are Schaumann bodies?

In pathology, Schaumann bodies are calcium and protein inclusions inside of Langhans giant cells as part of a granuloma. Many conditions can cause Schaumann bodies, including: Sarcoidosis, Hypersensitivity pneumonitis, and. Berylliosis.

Which body is affected by sarcoidosis?

Sir, Asteroid bodies and Schaumann bodies are commonly seen in sarcoidosis in histologic sections. However, the same are rarely seen in cytologic material.

What is Rose gardeners disease?

Sporotrichosis (also known as “rose gardener’s disease”) is an infection caused by a fungus called Sporothrix. This fungus lives throughout the world in soil and on plant matter such as sphagnum moss, rose bushes, and hay. 1 , 2.

Can Sporotrichosis be cured?

The usual treatment for sporotrichosis is oral itraconazole (Sporanox) for about three to six months; other treatments include supersaturated potassium iodide and amphotericin B in patients with more severe disease.

What is granuloma?

A granuloma is a small area of inflammation. Granulomas are often found incidentally on an X-ray or other imaging test done for a different reason. Typically, granulomas are noncancerous (benign). Granulomas frequently occur in the lungs, but can occur in other parts of the body and head as well.

What is Caseating granuloma?

Caseating granuloma means necrosis involving dead cells with no nuclei and debris. Without microscope, the cheese like pattern was seen in the these granulomas . In all reports of the CREMO patients, the granulomas were noncaseating .

What are epithelioid histiocytes?

Epithelioid histiocytes (Epithelioid cells) are activated macrophages resembling epithelial cells: elongated, with finely granular, pale eosinophilic (pink) cytoplasm and central, ovoid nucleus(oval or elongate), which is less dense than that of a lymphocyte.

What are the 4 stages of sarcoidosis?

Stage I: Lymphadenopathy (enlarged lymph nodes) Stage II: Enlarged lymph nodes with shadows on chest X-ray due to lung infiltrates or granulomas. Stage III: Chest X-ray shows lung infiltrates as shadows, which is a progressive condition. Stage IV (Endstage): Pulmonary fibrosis or scar-like tissue found on a chest X-ray …

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What causes sarcoidosis flare ups?

Some people appear to have a genetic predisposition to develop the disease, which may be triggered by bacteria, viruses, dust or chemicals. This triggers an overreaction of your immune system, and immune cells begin to collect in a pattern of inflammation called granulomas.

How does vitamin D affect sarcoidosis?

Vitamin D dysregulation is common in sarcoidosis patients. This is a result of the increase in an enzyme that converts the inactive form of vitamin D into the active form. Doctors often misread vitamin D levels in sarcoidosis patients which can lead to hypercalciumia or hypercalciuria.

Do I have sporotrichosis?

The symptoms of sporotrichosis often start off mild within the first several weeks of exposure. You’ll experience a small bump that can be red, pink, or purple. This bump appears at the site of exposure, usually on your arm or hand, and may or may not be painful to the touch.

WHY DO rose thorns hurt so bad?

The fungus can spread to the lymphatic system and move on to the joints and bones, where it ends up attacking the central nervous system and lungs when the thorn or thorns are deeply embedded.

What is sporotrichosis cats?

Sporotrichosis is a fungal infection that can affect humans, cats, and other mammals. It typically causes skin lesions, but it can also spread into the nasal mucosa and lymph nodes and even cause disseminated infections that involve the bones, lungs, or central nervous system.

What medication is used for sporotrichosis?

Itraconazole is the drug of choice for all types of sporotrichosis but CNS and disseminated sporotrichosis. Terbinafine has been demonstrated to be effective in the treatment of lymphocutaneous sporotrichosis, but no comparative data with itraconazole therapy exist.

What causes Zygomycosis?

Zygomycosis is any infection caused by fungi in the class Zygomycetes commonly found in soil or decomposing vegetation and animal matter. There are two major orders of Zygomycetes that cause infection in humans — Mucorales and Entomophthorales.

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What is the first line recommended treatment for sporotrichosis?

Saturated solution of potassium iodide remains a first line treatment choice for uncomplicated cutaneous sporotrichosis in resource poor countries but itraconazole is currently used/recommended for the treatment of all forms of sporotrichosis.

What do granulomas look like?

Granuloma annulare appears as small (1–3 mm), skin-colored or pink bumps. These bumps, which are smooth rather than scaly, may occur singly or in groups. Each bump may expand in size, leaving a shallow indentation in the center, which may be lighter or darker than your normal skin color.

Is granuloma a tumor?

A granuloma is a tiny cluster of white blood cells and other tissue that can be found in the lungs, head, skin or other parts of the body in some people. Granulomas are not cancerous. They form as a reaction to infections, inflammation, irritants or foreign objects.

What diseases cause granulomas?

Relatively few bacterial infections typically cause granulomas during infection, including brucellosis, Q-fever, cat-scratch disease (33) (Bartonella), melioidosis, Whipple’s disease (20), nocardiosis and actinomycosis.

What are calcified granulomas?

A calcified granuloma is a specific type of tissue inflammation that has become calcified over time. When something is referred to as “calcified,” it means that it contains deposits of the element calcium. Calcium has a tendency to collect in tissue that is healing.

What is a pyogenic granuloma?

Pyogenic granulomas are small, raised, and red bumps on the skin. The bumps have a smooth surface and may be moist. They bleed easily because of the high number of blood vessels at the site. It is a benign (noncancerous) growth. Pyogenic granulomas are skin lesions that can develop after an injury.

What is miliary tuberculosis?

Miliary tuberculosis (TB) is the widespread dissemination of Mycobacterium tuberculosis (see the image below) via hematogenous spread. Classic miliary TB is defined as milletlike (mean, 2 mm; range, 1-5 mm) seeding of TB bacilli in the lung, as evidenced on chest radiography.

What are foamy macrophages?

Foam cells are a type of macrophage that localize to fatty deposits on blood vessel walls, where they ingest low-density lipoproteins and become laden with lipids, giving them a foamy appearance.

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What is a multinucleated giant cell?

Multinucleated giant cells (MNGCs) are a special class of giant cell formed by the fusion of monocytes/macrophages abundantly found in human tissues. … Keywords: biomaterial integration; bone regeneration; foreign body cells; macrophage; multinucleated giant cells; osteoimmunology.

What is granulomatous lymphadenitis?

Introduction: Granulomatous lymphadenitis is a chronic inflammatory condition that can be associated with lymphoproliferative, infectious and autoimmune diseases. An accurate diagnosis is highly desirable in order to define the precise treatment. Objectives: The achievement of an etiology can be highly unpredictable.

What foods to avoid with sarcoidosis?

Things to Avoid in Your Diet

  • Refrain from eating foods with refined grains, such as white bread and pasta.
  • Cut back on red meat.
  • Avoid foods with trans-fatty acids, such as commercially processed baked goods, french fries, and margarine.
  • Stay away from caffeine, tobacco, and alcohol.

Is sarcoidosis a death sentence?

Sarcoidosis is not a death sentence! In fact, once diagnosed, your doctor’s first question will be to determine how extensive the disease is, and whether or not to treat at all – in many cases the choice will be to do nothing but watch carefully and allow the disease to go into remission on its own.

What is Caplan syndrome?

Rheumatoid pneumoconiosis (RP, also known as Caplan syndrome) is swelling (inflammation) and scarring of the lungs. It occurs in people with rheumatoid arthritis who have breathed in dust, such as from coal (coal worker’s pneumoconiosis) or silica.