What are the direct-acting antivirals?

Direct Acting Antivirals

Drug Drug Description
Adefovir dipivoxil A nucleotide analog used to treat chronic hepatitis B.
Ribavirin A guanosine nucleoside used to treat some forms of Hepatitis C.
Emtricitabine A nucleoside reverse transcriptase inhibitor used for the treatment and prophylaxis of HIV.

What are direct-acting agents?

Direct-acting antivirals (DAAs) are a newer class of drugs used to treat hepatitis C. DAAs target specific steps in the hepatitis C virus (HCV) life cycle. DAAs have shorter treatment times, fewer side effects, and higher SVR rates than older drugs.

Is Harvoni a direct-acting antiviral?

Zepatier, Harvoni, and Sovaldi are direct-acting antiviral (DAA) agents that treat HCV.

Is Sofosbuvir a direct-acting antiviral?

Sofosbuvir-based direct-acting antiviral therapy revolutionized the treatment of hepatitis C virus (HCV) infection.

Is Epclusa a direct acting antiviral?

NS3/4A protease inhibitors. … Classification of Direct-Acting Antiviral Agents in HCV Treatment Regimens Hepatitis C.

DAA Trade Name DAA Generic Name Abbreviation
Epclusa sofosbuvir/velpatasvir SOF/VEL
VoseviTM sofosbuvir/velpatasvir/voxilaprevir SOF/VEL/VOX
MavyretTM glecaprevir/pibrentasvir GLE/PIB

Is Harvoni a DAA?

Harvoni is a drug called a direct-acting antiviral (DAA).

What is the antiviral drug ribavirin?

Ribavirin, also known as tribavirin, is an antiviral medication used to treat RSV infection, hepatitis C and some viral hemorrhagic fevers. For hepatitis C, it is used in combination with other medications such as simeprevir, sofosbuvir, peginterferon alfa-2b or peginterferon alfa-2a.

How many classes of HCV direct acting antiviral drugs have been approved by the FDA?

There are four classes of DAAs, which are defined by their mechanism of action and therapeutic target. The four classes are nonstructural proteins 3/4A (NS3/4A) protease inhibitors (PIs), NS5B nucleoside polymerase inhibitors (NPIs), NS5B non-nucleoside polymerase inhibitors (NNPIs), and NS5A inhibitors [1].

Is Hep C curable?

Today, chronic HCV is usually curable with oral medications taken every day for two to six months. Still, about half of people with HCV don’t know they’re infected, mainly because they have no symptoms, which can take decades to appear.

What is the generic name for Harvoni?

Generic Name: ledipasvir-sofosbuvir This medication is a combination of ledipasvir and sofosbuvir and is used to treat chronic (long-lasting) hepatitis C, a viral infection of the liver.

What is the difference between Harvoni and Epclusa?

Both Epclusa and Harvoni are antiviral medications used for the treatment of hepatitis C. Epclusa contains sofosbuvir and velpatasvir and Harvoni contains sofosbuvir and ledipasvir. Sofosbuvir is an antiviral drug that is considered the backbone of hepatitis C treatment.

What is NS5A and NS5B?

The hepatitis C virus (HCV) NS5B protein contains the RNA dependent RNA polymerase (RdRp) activity that catalyzes the synthesis of the viral genome with other host and viral factors. NS5A is an HCV-encoded protein previously shown to localize to the replisome and be necessary for viral replication.

What is NS5A inhibitor?

What are NS5A inhibitors? Non-structural protein 5A (NS5A) inhibitors are a direct-acting antiviral agent used to treat hepatitis C virus (HCV). The NS5A protein has a substantial role in viral replication, packaging, assembly and complex interactions with cellular functions.

Who makes Vosevi?

The manufacturer of Vosevi, Gilead Sciences, states that there have been cases of problems in some people who have taken the heart drug amiodarone and medicines containing sofosbuvir. Vosevi contains sofosbuvir.

What is antiviral medication for hepatitis B?

Treatment for chronic hepatitis B may include: Antiviral medications. Several antiviral medications including entecavir (Baraclude), tenofovir (Viread), lamivudine (Epivir), adefovir (Hepsera) and telbivudine (Tyzeka) can help fight the virus and slow its ability to damage your liver.

What is the generic for Epclusa?

Generic Name: sofosbuvir-velpatasvir.

Is Biktarvy a cure?

BIKTARVY is a complete, 1-pill, once-a-day prescription medicine used to treat HIV-1 in certain adults. BIKTARVY does not cure HIV-1 or AIDS. HIV-1 is the virus that causes AIDS.

What medicine should not be taken with Epclusa?

Amiodarone (a heart rhythm medicine) should not be taken with Epclusa because it can cause an abnormal slowing of the heart rate called bradycardia. Over-the-counter antacids or acid-reducing agents can reduce the effectiveness of Epclusa.

What is SVR medical?

Introduction. Peripheral vascular resistance (systemic vascular resistance, SVR) is the resistance in the circulatory system that is used to create blood pressure, the flow of blood and is also a component of cardiac function. When blood vessels constrict (vasoconstriction) this leads to an increase in SVR.

Can you take amoxicillin with Harvoni?

Interactions between your drugs No interactions were found between amoxicillin and Harvoni. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

What is the brand name of ribavirin?

Ribavirin is available under the following different brand names: Rebetol, Ribasphere, RibaPak, Copegus, Virazole, and Moderiba.

What is Ribazole capsule?

Therapeutic Segment: Anti-Viral. Generic Name: Ribavirin. Indication: In combination with Interferon alfa-2b and Peginterferon alfa-2a for the treatment of patients 3 years of age and older with chronic Hepatitis C (CHC) who have compensated liver disease.

Who should not handle ribavirin?

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk. Ribavirin is not approved for use by anyone younger than 3 years old. Ribavirin tablets are not approved for use by anyone younger than 5 years old.

Is sofosbuvir DAA?

One of the most potent DAA medications is sofosbuvir, a pan-genotypic nucleotide analogue that inhibits the NS5B polymerase of HCV. Daclatasvir, a pan-genotypic inhibitor of the HCV NS5A replication complex, was recently approved in the United States for treatment of HCV genotype 3 in conjunction with sofosbuvir.

What is the drug that cures Hep C?

More people have been prescribed HARVONI to cure their Hep C than any other advanced treatment regimen. * HARVONI transformed Hep C treatment as the first cure with a simple regimen that’s one pill, once a day for 12 weeks for the majority of patients.

What is Harvoni for hep C?

Harvoni is a combination pill made up of the drugs ledipasvir and sofosbuvir. As DAAs, these drugs work by interfering with the action of a protein needed for the growth of HCV. This prevents HCV from multiplying. Harvoni is used to treat people with HCV genotypes 1, 4, 5, and 6.

What kills Hep C?

Bleach kills HCV nearly all the time, and there are other cleaners or disinfectants you can use, too, that also work against the virus. Bleach: Bleach has been shown to kill HCV in more than 99% of contaminated syringes.

Which Hepatitis is incurable?

How to prevent hepatitis B. Hepatitis B is a liver infection caused by a virus (called the hepatitis B virus, or HBV). It can be serious and there’s no cure, but the good news is it’s easy to prevent.

Where did Hep C come from?

HCV origin was previously dated in a range between 200 and 1000 years ago. Hepaciviruses have been identified in several domestic and wild mammals, the largest viral diversity being observed in bats and rodents. The closest relatives of HCV were found in horses/donkeys (equine hepaciviruses, EHV).