What causes hypogonadotropic hypogonadism?

Acquired hypogonadotropic hypogonadism can be caused by drugs, infiltrative or infectious pituitary lesions, hyperprolactinemia, encephalic trauma, pituitary/brain radiation, exhausting exercise, abusive alcohol or illicit drug intake, and systemic diseases such as hemochromatosis, sarcoidosis and histiocytosis X. What is another name for hypogonadotropic hypogonadism?
Hypogonadotropic hypogonadism (HH), is due to problems with either the hypothalamus or pituitary gland affecting the hypothalamic-pituitary-gonadal axis (HPG axis). …

Hypogonadotropic hypogonadism
Other names Secondary hypogonadism

What is the main cause of hypogonadism?

Primary hypogonadism originates from a problem with the testes or the ovaries, causing the sex glands to produce fewer sex hormones. Secondary hypogonadism, also known as hypogonadotropic hypogonadism, is caused by a problem with the pituitary gland or hypothalamus. Is hypogonadotropic hypogonadism reversible?
Congenital hypogonadotropic hypogonadism (CHH) is characterized by lack of puberty and infertility. Traditionally, it has been considered a life-long condition yet cases of reversibility have been described wherein patients spontaneously recover function of the reproductive axis following treatment.

Can you get pregnant with hypogonadotropic hypogonadism?

Overall, there is an excellent chance in achieving a pregnancy for women with hypogonadotropic hypogonadism. What is the difference between hypogonadotropic hypogonadism and hypogonadism?

Hypogonadism is a condition in which the male testes or the female ovaries produce little or no sex hormones. Hypogonadotropic hypogonadism (HH) is a form of hypogonadism that is due to a problem with the pituitary gland or hypothalamus.

Frequently Asked Questions(FAQ)

What is the treatment for hypogonadotropic hypogonadism?

Male hypogonadotropic hypogonadism (MHH), a disorder associated with infertility, is treated with testosterone replacement therapy (TRT) and/or gonadotropins replacement therapy (GRT) (TRT and GRT, together with HRT hormone replacement therapy).

What is secondary hypogonadotropic hypogonadism?

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Hypogonadotropic hypogonadism (HH) or secondary hypogonadism is defined as a clinical syndrome that results from gonadal failure due to abnormal pituitary gonadotropin levels. HH may result from either absent or inadequate hypothalamic GnRH secretion or failure of pituitary gonadotropin secretion.

What does Hypogonadotropic mean?

[hi″po-gon″ah-do-trōp´ik] relating to or caused by deficiency of gonadotropin.

What is hypogonadotropic amenorrhea?

hypogonadotropic amenorrhea cessation of menstruation due to failure to maintain a critical body fat-to-lean ratio, resulting in hypothalamic suppression; seen in women who engage in strenuous exercise, such as athletes, dancers, and those who are excessively weight conscious.

What causes Hypergonadism?

What diseases can cause hypogonadism?

Common causes of primary hypogonadism include:

  • Klinefelter syndrome. This condition results from a congenital abnormality of the sex chromosomes, X and Y. …
  • Undescended testicles. …
  • Mumps orchitis. …
  • Hemochromatosis. …
  • Injury to the testicles. …
  • Cancer treatment.

How does hypogonadism affect the body?

[1] Male hypogonadism is characterized by a deficiency in testosterone – a critical hormone for sexual, cognitive, and body function and development. Clinically low testosterone levels can lead to the absence of secondary sex characteristics, infertility, muscle wasting, and other abnormalities.

How do you pronounce hypogonadotropic hypogonadism?

What are the symptoms of hypogonadism in males?

Symptoms of adult-onset hypogonadism include:

  • erectile dysfunction.
  • low sperm count.
  • depressed mood.
  • decreased libido.
  • lethargy.
  • sleep disturbances.
  • decreased muscle mass and strength.
  • loss of body hair (pubic, axillary, facial)

Can hypogonadism be cured naturally?

Men diagnosed with hypogonadism can benefit from testosterone therapy. Therapy isn’t usually recommended, however, if your testosterone levels fall within the normal range for your age. There’s no magic solution for boosting your testosterone, but some natural remedies may help.

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Can male hypogonadism reversed?

It is believed that lifelong hormone therapy is required to maintain sexual function and secondary sexual characteristics in men with idiopathic hypogonadotropic hypogonadism. However, rare cases of spontaneous reversal of this condition later in life have been reported.

What is anovulation?

Anovulation happens when an egg (ovum) doesn’t release from your ovary during your menstrual cycle. An egg is needed to have a pregnancy. Since multiple hormones are involved in ovulation, there are many causes of anovulation. Chronic anovulation is a common cause of infertility.

What is secondary hypogonadism in females?

Primary hypogonadism refers to a condition of the ovaries (primary ovarian insufficiency/hypergonadotropic hypogonadism). Secondary hypogonadism refers to the failure of the hypothalamus or pituitary gland (hypogonadotropic hypogonadism).

What is Hypergonadotropic hypogonadism?

Introduction. In men, hypergonadotropic hypogonadism is a failure of the testes to produce sufficient quantities of testosterone. As part of the feedback response, the pituitary is stimulated to secrete higher levels of the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH).

Is Klinefelter hypogonadotropic hypogonadism?

Klinefelter’s syndrome is characterized by hypergonadotropic hypogonadism, 47,XXY karyotype, gynecomastia, azoospermia and testicular atrophy with hyalinization of seminiferous tubules and hyperplasia of Leydig cells.

What is GnRH?

A hormone made by a part of the brain called the hypothalamus. GnRH causes the pituitary gland in the brain to make and secrete the hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). In men, these hormones cause the testicles to make testosterone.

What is Sheehan syndrome?

Sheehan’s syndrome is a condition that affects women who lose a life-threatening amount of blood in childbirth or who have severe low blood pressure during or after childbirth, which can deprive the body of oxygen. This lack of oxygen that causes damage to the pituitary gland is known as Sheehan’s syndrome.

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What happens when GnRH is low?

Any deficiency, whether total or partial, in the production of GnRH can lead to a failure of puberty which in turn can lead to a lack of sexual development and infertility. Pubertal failure might be total or partial depending on the degree of GnRH deficiency. GnRH deficient conditions can affect both men and women.

What causes low LH and FSH in males?

The excessive amount of testosterone or estradiol can inhibit FSH and LH secretion. Intentional (iatrogenic) secondary hypogonadism: Prolonged administration of high doses of anabolic steroids (by athletes) or GnRH analogs (for prostate cancer) can cause low FSH or LH levels.

What happens when there is too much GnRH?

Research is still being conducted on the effects of having too much GnRH. In rare cases, pituitary tumors can develop, which increases the production of gonadotropins (LH and FSH), which might cause the body to overproduce testosterone and estrogen.

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