High and persistent MOG antibody titers are more likely to predict a relapsing course. The rate of relapsing disease varies by series, but has been reported to be as high as 72-88%. 10 , 12. The overall prognosis of MOG is favorable compared to AQP4 positive disease with better recovery and less disability.
What are the symptoms of MOG?
Signs & Symptoms
- Loss or blurring of vision in one or both eyes.
- Loss of color vision.
- Paralysis (no motor function) of a limb or limbs.
- Paraparesis (weakness) of a limb or limbs.
- Loss of sensation.
- Loss of bladder or bowel control.
- Profound bladder retention.
- Seizures. 4 , 9
What is the difference between NMO and MOG?
MOG-EM differs from NMOSD in further clinical characteristics e.g., in gender ratio and age at onset. In (relapsing) NMOSD, up to 90% of the patients are female, whereas the proportion of male patients in MOG-EM ranges from 43 to 63% (22, 26, 29–31, 73).
Is MOG disease fatal?
Although it can be treated, it is very devastating and sometimes fatal. It is important to know that exposure to these medications in MOG antibody disease has not led to a known case of PML.
How serious is MOG disease?
In MOG antibody demyelination, MOG antibodies attack the myelin oligodendrocyte glycoprotein, causing damage to the myelin sheath. AQP4 antibody NMO is highly likely to cause repeated attacks, which can cause severe disability if it is not treated.
What is the treatment for MOG?
How is MOG antibody demyelination treated? Intravenous steroid treatment is often used to treat the acute symptoms of demyelination to try to reduce the inflammation that has occurred. This will usually be given at high dose for three to five days via a cannula into a vein.
Is anti MOG curable?
Many individuals with anti-MOG syndrome will recover fully after their first treatment and never relapse. However, some patients may experience recurrent attacks and need a long-term management plan. This may include IVIG and medication, such as azathioprine, myucophenolate mofetil, or rituximab.
Is MOG disease progressive?
MOG-IgG-related entities are considered part of the NMOSD (16–19) and progressive deterioration has been described rarely (4, 13).
What is considered a high MOG titer?
Moreover, high levels of MOG-IgG antibodies (≥1:160) indicate that patients with an initial ON event will not develop a chronic demyelinating disease, such as MS or NMO, offering an additional tool in the differential diagnosis.
What is MOG in neurology?
Myelin oligodendrocyte glycoprotein (MOG) is a glycoprotein located on the myelin surface and found exclusively in the central nervous system (CNS) [1, 2].
What does anti MOG mean?
Neuromyelitis optica spectrum disorder (NMOSD) and anti-myelin oligodendrocyte glycoprotein (anti-MOG) syndromes are immune-mediated inflammatory conditions of the central nervous system that frequently involve the optic nerves and the spinal cord.
Is MOG disease a disability?
MOG-antibody disease has a moderate relapse risk, which might be mitigated by medium term immunosuppression at onset. Permanent disability occurs in about half of patients and more often involves sphincter and erectile functions than vision or mobility. Topic: encephalomyelitis, acute disseminated.
How many people in the world have MOG?
A recent Dutch nationwide study reported the annual incidence of MOG-antibody disease as 1.6/million population (adult: 1.3/million, children: 3.1/million).
What happens when demyelination occurs?
Demyelination is loss of myelin, a type of fatty tissue that surrounds and protects nerves throughout the body. This condition causes neurological deficits, such as vision changes, weakness, altered sensation, and behavioral or cognitive (thinking) problems.
Does ADEM cause brain damage?
ADEM typically damages white matter (brain tissue that takes its name from the white color of myelin), leading to neurological symptoms such as visual loss (due to inflammation of the optic nerve) in one or both eyes, weakness even to the point of paralysis, and difficulty coordinating voluntary muscle movements (such …
Can you live a long life with NMO?
It’s possible to live for many years with NMO, especially if you receive treatment early on with immune-modulating medications. Some people develop life threatening complications from NMO. One small study found that about 1 in 5 people with NMO develop breathing difficulties.
Does NMO shorten life expectancy?
The life expectancy of a person with NMO varies widely. Past studies have suggested that the natural 5-year mortality rate for NMO is about 22–30%, according to a 2021 research review. More recent research suggests that with treatment the rate declines to 3–7%.
Which is worse MS or NMO?
Symptoms of NMO are usually severe than multiple sclerosis (MS). The individual episodes in NMO are more serious compared to MS. Their cumulative effect will have debilitating, irreversible effects on nerve functions.
What is cervical myelitis?
Cervical myelopathy results from compression of the spinal cord in the neck (cervical area of the spine). Symptoms of cervical myelopathy may include problems with fine motor skills, pain or stiffness in the neck, loss of balance, and trouble walking.
Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with Sun’Agri and INRAE in Avignon between 2019 and 2022. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. I love to write and share science related Stuff Here on my Website. I am currently continuing at Sun’Agri as an R&D engineer.