What does Nectin do?
Nectins are a family of immunoglobulin-like transmembrane proteins, which function as a calcium-independent way to promote cellcell adhesion (Nakanishi and Takai, 2004).
What is CD112?
CD112 Function. Intracellular adhesion, component of adherins junctions. Receptor for herpes simplex virus. CD112 Summary. Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.[1]
Where is Nectin 4 found?
Although Nectin-1, 2, and 3 are widely expressed in normal adult tissues, Nectin-4, also known as PVRL4 (poliovirus-receptor-like 4), is expressed specifically in the embryo and placenta [15,16].
Where are adhesion junctions found?
Adherens junctions (or zonula adherens, intermediate junction, or belt desmosome) are protein complexes that occur at cellcell junctions, cellmatrix junctions in epithelial and endothelial tissues, usually more basal than tight junctions.
What is Trop2?
Trop2 is a transmembrane glycoprotein encoded by the Tacstd2 gene. It is an intracellular calcium signal transducer that is differentially expressed in many cancers. It signals cells for self-renewal, proliferation, invasion, and survival. It has stem cell-like qualities.
Where are poliovirus receptors found?
CD155 is also commonly referred to as the poliovirus receptor, or PVR. It is expressed on the surface of intestinal epithelial cells and on M cells of Peyer’s patches, which may facilitate their entry into the Peyer’s patches following infection of the intestinal epithelium.
What is com701?
A humanized, hybridoma monoclonal antibody against the poliovirus receptor-related immunoglobulin (PVRIG; PVR Related Immunoglobulin Domain Containing Protein; CD112R), with potential immune checkpoint inhibitory and antineoplastic activities.
What is adhesive junction example?
This diagram depicts three different examples of adherens junctions; punctum adherens that are common in mesenchymal and neural cells, zonula adherens that are common in endothelial and epithelial cells and tricellular adherens junction, common in all cell monolayers [Franke WW et al, 2009].
How many cell junctions are there?
In vertebrates, there are three major types of cell junction: Adherens junctions, desmosomes and hemidesmosomes (anchoring junctions) Gap junctions (communicating junction) Tight junctions (occluding junctions)
What is the strongest cell junction?
Desmosomes are even stronger connections that join the intermediate filaments of neighboring cells.
What is TNBC?
Triple-negative breast cancer (TNBC) accounts for about 10-15% of all breast cancers. The term triple-negative breast cancer refers to the fact that the cancer cells don’t have estrogen or progesterone receptors and also don’t make too much of the protein called HER2.
Is TROP2 a biomarker?
Trop-2 Overexpression as a Valuable Biomarker in Solid Tumors. Trop-2 is inextricably linked to cancer progression and metastasis because of its role as a key regulator of the hallmarks of cancer, including cell growth, proliferation, migration, invasion, and survival.
What is TROP2 protein?
TROP2 is a single-copy gene in human cells that encodes type I transmembrane glycoprotein, which is overexpressed in various malignant tumors. It is a gene closely related to tumor discovered in recent years, which is a signaling molecule that can regulate the growth of tumor cells.
How does poliovirus enter the cell?
By testing inhibitors known to target specific enzymes, future studies can determine which one poliovirus hijacks to infect cells. Altogether, these results suggest that the poliovirus enters the cell after binding to the cell surface, then rapidly releases it genome from vesicles near the membrane.
What is cell receptor for poliovirus?
The human poliovirus receptor (PVR) is a cell surface protein with a multitude of functions in human biology. PVR was initially identified as the receptor for the human poliovirus and recent discoveries have given a greater insight into both its morphology and its function.
How is the polio virus transmitted?
Poliovirus only infects people. It enters the body through the mouth and spreads through: Contact with the feces (poop) of an infected person. Droplets from a sneeze or cough of an infected person (less common).
Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with Sun’Agri and INRAE in Avignon between 2019 and 2022. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. I love to write and share science related Stuff Here on my Website. I am currently continuing at Sun’Agri as an R&D engineer.