What drug group is atorvastatin?

Atorvastatin belongs to a group of medicines called statins. It’s used to lower cholesterol if you’ve been diagnosed with high blood cholesterol.

What is the functional group of simvastatin?

esters Simvastatin is also a nonpolar molecule. Its functional groups include two esters and an alcohol. The pKa’s are 16 and 25 respectively.

How many functional groups are in simvastatin?

This drug is com- prised of seven parts or seven specific functional groups.

What is the chemical structure of atorvastatin?

Atorvastatin calcium is [R-(R*, R*)]-2-(4-fluorophenyl)-ß, δ-dihydroxy-5- (1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid, calcium salt (2:1) trihydrate. The empirical formula of atorvastatin calcium is (C33H34 FN2O5)2Ca•3H2O and its molecular weight is 1209.42.

Is atorvastatin a beta blocker?

Beta-blockers (atenolol) and statins (atorvastatin) are widely used to combat hypertension and dyslipidaemia, particularly in obese patients who are also prone to diabetes and coronary artery disease.

What is atorvastatin 40mg tablets used for?

Atorvastatin is used along with a proper diet to help lower bad cholesterol and fats (such as LDL, triglycerides) and raise good cholesterol (HDL) in the blood. It belongs to a group of drugs known as statins. It works by reducing the amount of cholesterol made by the liver.

Is simvastatin and atorvastatin the same?

Atorvastatin and simvastatin are both effective statin drugs for lowering blood cholesterol. However, atorvastatin is considered a more potent statin. Atorvastatin lasts longer in the body and can be taken in the morning or at night.

Is atorvastatin a prodrug?

Unlike the previously introduced prodrugs , lovastatin and simvastatin, which are inactive till get metabolised, atorvastatin is an active compound. The statins inhibit competitively an enzyme (HMG-CoA reductase) in the liver that converts HMG-CoA to mevalonic acid, an early precursor of cholesterol.

What are the functional groups in rosuvastatin?

A dihydroxy monocarboxylic acid that is (6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl} hept-6-enoic acid carrying two hydroxy substituents at positions 3 and 5 (the 3R,5S-diastereomer).

How many stereoisomers are possible for simvastatin?

Statins have two chiral centers in their molecules, thus they form four enantiomers (3R5R-, 3R5S-, 3S5R- and 3S5S-).

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What is rosuvastatin 20mg?

Rosuvastatin is used along with a proper diet to help lower bad cholesterol and fats (such as LDL, triglycerides) and raise good cholesterol (HDL) in the blood. It belongs to a group of drugs known as statins. It works by reducing the amount of cholesterol made by the liver.

What are the drugs under the same class as simvastatin?

BACKGROUND: Statins are a class of prescription medicines that have been used for decades to lower low-density lipoprotein (LDL-C or bad) cholesterol in the blood. Medicines in the statin class include atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin.

What is the action of atorvastatin?

Atorvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

How is atorvastatin synthesized?

[18F]Atorvastatin was synthesized via an optimized ruthenium-mediated late-stage 18F-deoxyfluorination. The defluoro-hydroxy precursor was produced via Paal-Knorr pyrrole synthesis and was followed by coordination of the phenol to a ruthenium complex, affording the labeling precursor in approximately 10% overall yield.

Is atorvastatin an enzyme inhibitor?

Atorvastatin is a statin medication and a competitive inhibitor of the enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol biosynthesis.

Is diltiazem a beta-blocker?

Metoprolol and diltiazem belong to different drug classes. Metoprolol is a beta-blocker (beta-adrenergic blocking agent) and diltiazem is a calcium channel blocker (CCB). Side effects of metoprolol and diltiazem that are similar include constipation, nausea, and low blood pressure (hypotension).

What is atorvastatin beta-blocker?

Atorvastatin is used along with a proper diet to help lower bad cholesterol and fats (such as LDL, triglycerides) and raise good cholesterol (HDL) in the blood. It belongs to a group of drugs known as statins. It works by reducing the amount of cholesterol made by the liver.

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Can you take a statin and a beta-blocker together?

There is no interaction between beta-blocker use and the benefit of statins on cardiovascular outcomes, according to a research letter published Aug. 18 in the Journal of the American College of Cardiology.

Is 40 mg of atorvastatin a lot?

Conclusions: Atorvastatin in daily dose of 40 mg is a safe and well tolerable medication for the treatment for dyslipidemic disorders in patients of different clinic profile and cardiovascular risk groups in common medical practice.

Does atorvastatin lower blood pressure?

Atorvastatin significantly reduced 24-h systolic and diastolic BP (DBP; median (range)) as compared with placebo (-5.0 (-21.0, 4.0) vs +1.0 (-6.0, 7.0) mm Hg, P<0.001 and -3.0 (-16.0, 2.0) vs +0.1 (-7, 4) mm Hg, P<0.01, respectively).

Can I take atorvastatin 40 mg every other day?

Conclusion: Alternate-day treatment with atorvastatin is comparable in efficacy and safety to the established daily treatment regimen, thus being a cost effective alternative.

Can you switch from atorvastatin to simvastatin?

A large proportion of patients who switch from atorvastatin to simvastatin are prescribed doses that are not therapeutically equivalent, and these patients were significantly less likely to meet LDL-C treatment goals compared with patients who remained on atorvastatin.

Is Lipitor and atorvastatin the same?

Atorvastatin is an oral tablet you take by mouth once a day to help lower your cholesterol. It is a prescription drug and comes as a generic and brand name (Lipitor) product. Both products come in strengths of 10 mg, 20 mg, 40 mg, and 80 mg.

Is simvastatin stronger than atorvastatin?

Dose for dose, atorvastatin is more potent than simvastatin at blocking the target enzyme, HMGCoA; this effect is overcome by using a higher dose of simvastatin. In controlled dosing studies, simvastatin 40 mg and atorvastatin 10 mg and 20 mg are equally effective.

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Are statins prodrugs?

Simvastatin and another statin, lovastatin, contain a lactone ring within their structure. Simvastatin is a prodrug that is administered in its inactive lactone form and converted in the body to an active beta-hydroxy acid metabolite Endo and Hasumi (1989).

Can Atorvastatin be dissolved in water?

Atorvastatin is a fairly hydrophobic molecule and unlikely to be water soluble at good concentration. However, it should be fairly easily soluble in DMSO.

Who makes atorvastatin?

Viatris, the maker of LIPITOR, is proud to offer the brand-name cholesterol medication that has been prescribed to over 29 million patients.

What class is rosuvastatin?

Rosuvastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of cholesterol that may build up on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Is rosuvastatin more effective than atorvastatin?

At the end of the titration-to-goal period, rosuvastatin was significantly more effective than atorvastatin on the primary efficacy measure, reducing LDL-C by 52% compared with 46% in the atorvastatin group (p < 0.0001) (table ​

Is rosuvastatin acid or base?

Rosuvastatin is a dihydroxy monocarboxylic acid that is (6E)-7-{4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-(propan-2-yl)pyrimidin-5-yl} hept-6-enoic acid carrying two hydroxy substituents at positions 3 and 5 (the 3R,5S-diastereomer).