Listen to pronunciation. (AN-tee-LIM-foh-site GLAH-byoo-lin) Serum from blood that contains antibodies that bind to human T cells. Antilymphocyte globulin is given to a patient before a stem cell transplant to kill T cells and lower the risk of graft-versus-host disease (GVHD).
Why are antilymphocyte serum given?
(antilymphocyte globulin, ALS, ALG) an antiserum, containing antibodies that suppress lymphocytic activity, prepared by injecting an animal with lymphocytes. ALS may be given to a patient to prevent the immune reaction that causes tissue rejection following transplantation of such organs as kidneys or of bone marrow.
What is Atgam?
Atgam is a polyclonal antibody, or an immune globulin, given as an intravenous (IV, into a vein) infusion. Atgam is used to fight a type of white blood cell called a T-lymphocyte (also called a thymocyte or T-cell). T-lymphocytes are part of your immune system.
Is Atgam hazardous?
Because Atgam is made from equine and human blood components, it may carry a risk of transmitting infectious agents, e.g., viruses, and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent.
How do you mix Atgam?
Add the total daily dose of ATGAM to the sterile vehicle (see Compatibility and Stability). The concentration should not exceed 4 mg of ATGAM per mL. The diluted solution should be gently rotated or swirled to effect thorough mixing. The diluted ATGAM should be allowed to reach room temperature before infusion.
How is Antithymocyte globulin given?
Background. Antithymocyte globulin is a hyperimmune globulin preparation made from plasma of rabbits or horses that have been immunized with human thymocytes or T cells. ATG is given by infusion only and leads to a rapid decrease in circulating T cells.
Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with Sun’Agri and INRAE in Avignon between 2019 and 2022. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. I love to write and share science related Stuff Here on my Website. I am currently continuing at Sun’Agri as an R&D engineer.