Apigenin has been used as a traditional medicine for centuries because of its physiological functions as an antioxidant and anti-inflammatory [6, 7], its role in lowering blood pressure [8], and its antibacterial and antiviral properties [9].
Are chamomile and apigenin the same?
Apigenin (Figure 2(a)) is a common flavonoid found in a range of plants, including chamomile (Matricaria recutita). The traditional use of chamomile tea as a treatment for insomnia and anxiety led to investigations of its active constituents, including apigenin.
Is apigenin a sedative?
Among all the administered doses of apigenin, 0.6 mg/kg demonstrated a sedative effect (F4.35 = 2.657, p = 0.0490), resulting in a significant increase in the sleeping duration (Fig. 3).
Should I take apigenin?
Apigenin is considered safe when consumed in normal amounts through a diet rich in fruits, vegetables and herbs. However, supplement doses tend to deliver a significantly higher amount of apigenin than would be generally consumed via dietary means.
Does apigenin increase GABA?
Recent studies on human recombinant receptors in oocytes have shown that apigenin inhibited the activation of GABAA receptors in a flumazenil-insensitive manner and had a similar effect on GABAC receptors.
Does apigenin help with sleep?
Thus, apigenin may have direct, positive effects on diseases such as AD or insomnia.
Does apigenin cross the blood brain barrier?
Apigenin does cross the blood-brain-barrier [7]. A randomized controlled trial of 14 healthy volunteers showed that parsley supplementation for 2 weeks resulted in increased antioxidant capacity in the plasma (by increasing activities of erythrocyte glutathione reductase and superoxide dismutase) [8].
What is the best source of apigenin?
Apigenin is abundant in a variety of natural sources, including fruits and vegetables. The best sources of apigenin are parsley, chamomile, celery, vine-spinach, artichokes, and oregano, and the richest sources are in the dried forms [14, 15].
Does apigenin increase testosterone?
As shown in Fig. 1C, apigenin significantly increased testosterone production in mouse Leydig cells cultured in the medium containing 0.01 mM dbcAMP.
Does apigenin lower blood pressure?
These data demonstrate that dietary apigenin decreases high blood pressure and improves endothelium-dependent relaxation in the DOCA-salt …
How does apigenin work?
The research team conducted by Rehen demonstrated that apigenin works by binding to estrogen receptors, which affect the development, maturation, function, and plasticity of the nervous system.
How much apigenin is in chamomile powder?
Optimum chamomile extracts contain about 50 percent alcohol. Normally standardized extracts contain 1.2% of apigenin which is one of the most effective bioactive agents.
Is apigenin a benzodiazepine?
Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med. 1995 Jun;61(3):213-6.
Does chamomile increase GABA?
Regardless the reason recent studies confirm what has been proposed for centuries chamomile effectively helps to decrease mild to moderate anxiety and it influences GABA receptors to produce a sedative effect.
Is apigenin antiviral?
Apigenin exhibits various antiviral activities against numerous viruses in vitro and in vivo: enterovirus 71 (EV71) [26,28], hepatitis C virus (HCV) [41,46], Human Immunodeficiency Virus (HIV) [47], and adenoviruses [48].
How much apigenin is in a cup of chamomile tea?
In addition, apigenin and the extract of chamomile ligulate flowers were shown to have a cytotoxic activity against human rhabdomyosarcoma and human cervix carcinoma Hep2c (Cvetanović et al., 2015). One cup (200 ml) of chamomile tea contains up to 9.3 mg of apigenin glu- cosides (Raal et al., 2012).
How does chamomile affect the brain?
The sedative nature of the plant calms nerves and reduces anxiety. Inhaling chamomile vapours from using the chamomile oil or drinking chamomile tea, helps the herb to bind with the benzodiazepine receptors in the brain, acting as a mild sedative and hypnotic agent.
Does chamomile contain quercetin?
Chamomile contains polyphenols. Polyphenols are naturally occurring chemicals in plants that act as antioxidants. The main polyphenols found in chamomile are apigenin, quercetin, patuletin and luteolin. Apigenin is found in chamomile and is reported to have anxiety reducing effects.
How much Fisetin is in strawberries?
The highest concentration of fisetin was found in strawberries (160 μg/g) followed by apple (26.9 μg/g) and persimmon (10.5 μg/g) (33).
Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with Sun’Agri and INRAE in Avignon between 2019 and 2022. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. I love to write and share science related Stuff Here on my Website. I am currently continuing at Sun’Agri as an R&D engineer.