What is azepine used for?

Seven membered heterocyclic rings containing a NITROGEN atom. For the treatment of hypertension. A psychotropic agent used for the management of bipolar disorder, schizophrenia, and major depressive disorder.

Why is azepine not aromatic?

It is (b) anti-aromatic because it has eight B-electrons (a 4n number) in a cyclic coplanar system of sp2 hybridized atoms. It is (c) non-aromatic because one of the ring atoms is sp2-hybridized (even though Dr. Bartmess’s calculation says otherwise), just as is the nitrogen in azepine.

What ring size is azepine?

One of the compounds, 1-(p-bromophenylsulfonyl)-1H-azepine, exists as a boat-shaped seven-membered ring containing alternate Csp (2)-Csp (2) single and double bonds.

What are derivatives of Azepines?

Introduction. Talipexole (B-HT 920), an azepine derivative, is an alpha-2 adrenergic receptor agonist and D₂ dopamine receptor agonist.

What is Azepine ring?

verify (what is ?) Infobox references. Azepines are unsaturated heterocycles of seven atoms, with a nitrogen replacing a carbon at one position.

Is 1H Azepine aromatic?

Geometrical and energetic DFT calculations as well as GIAO and NICS chemical shifts have been calculated for 1H-azepine and 5H-dibenz[b,f]azepine and their cations. … The conclusion is that the neutral molecules are antiaromatic while the cations are aromatic (homoheteroaromaticity).

Is the structure of Thiepine?

In organic chemistry, thiepine (or thiepin) is an unsaturated seven-membered heterocyclic compound, with six carbon atoms and one sulfur atom. The parent compound, C₆H₆S is unstable and is predicted to be antiaromatic. Bulky derivatives have been isolated and shown by X-ray crystallography to have nonplanar C₆S ring.

What is meant by Annulene?

An annulene is an unsubstituted monocyclic hydrocarbon whose Lewis structure has alternating double bonds and single bonds. An annulene can be named as [n]annulene where n is the number of carbon atoms in the molecule. see also aromatic annulene, antiaromatic annulene, nonaromatic annulene.

How do you name fused heterocyclic compounds?

The name of the heterocyclic ring is chosen as the parent compound and the name of the fused ring is attached as a prefix. The prefix in such names has the ending ‘o’, i.e., benzo, naphtho and so on.

How many members are in there for Azepine structure?

2.9. 1 Synthesis of Azepines. Azepines are seven-membered heterocycles with one nitrogen atom. This class of heterocyclic compounds is important because this scaffold is found in the molecular skeleton of many pharmaceuticals, such as cetiedil and mecillinam, and some natural products.

What are saturated heterocyclic compounds?

A heterocyclic compound is a cyclic compound that has atoms of at least two different elements as members of its ring. Fusion of two benzene rings gives rise to a third large family of compounds the acridine, dibenzothiophene, carbazole, and dibenzofuran. …

What is the use of quinoline?

Quinoline is used principally for the manufacture of nicotinic acid, which prevents pellagra in humans, and other chemicals. Several methods are known for its preparation, and production of synthetic quinoline exceeds that from coal tar.

What is a pyrrole ring?

pyrrole, any of a class of organic compounds of the heterocyclic series characterized by a ring structure composed of four carbon atoms and one nitrogen atom. … In heme and chlorophyll, four pyrrole rings are joined in a larger ring system known as porphyrin.

Is pyrazole acidic or basic?

Pyrazole is a weak base, with pK_b 11.5 (pK_a of the conjugated acid 2.49 at 25 °C). Pyrazoles are also a class of compounds that have the ring C₃N₂ with adjacent nitrogen atoms.

What is indole group?

Indole is an aromatic heterocyclic organic compound with formula C₈H₇N. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria.

Which heteroatom is present in thiophene ring?

hetero atom O and S is present in the ring respectively. Furan is a heterocycle containing oxygen which is employed primarily for the conversion to other substances including pyrrole. Thiophene is a sulphur containing heterocycle which resembles benzene in its chemical and physical properties.

Which heteroatom is present in thiophene?

It is a colorless liquid with a benzene-like odor. In most of its reactions, it resembles benzene. Compounds analogous to thiophene include furan (C₄H₄O) selenophene (C₄H₄Se) and pyrrole (C₄H₄NH), which each vary by the heteroatom in the ring.

Which of the following compound is a peptide containing Phenoxazine derivative?

Actinomycin D (dactinomycin) is a natural chromopeptide composed of a heterocyclic chromophore and two cyclic pentapeptide lactone rings. The heterocyclic fragment is a phenoxazine derivative, containing a quinonimine portion, and is responsible for the color of the compound and its intercalative ability.

Is pyridine volatile?

In daily life, trace amounts of pyridine are components of the volatile organic compounds that are produced in roasting and canning processes, e.g. in fried chicken, sukiyaki, roasted coffee, potato chips, and fried bacon.

Which of the following solvents is a heterocyclic compound *?

The best known of the simple heterocyclic compounds are pyridine, pyrrole, furan, and thiophene.

Which group is known as acetamido?

Acetamide (systematic name: ethanamide) is an organic compound with the formula CH₃CONH₂. It is the simplest amide derived from acetic acid.

What is a triazole ring?

A triazole refers to any of the heterocyclic compounds with molecular formula C₂H₃N₃, having a five-membered ring of two carbon atoms and three nitrogen atoms. … Each of these has two tautomers that differ by which nitrogen has a hydrogen bonded to it.

What are annulenes with examples?

Aromaticity of Annulenes Annulenes could be aromatic, anti-aromatic or non-aromatic. For example, [4] Annulene which is cyclobutadiene is anti-aromatic, [6] Annulene (Benzene) is aromatic and [8] Annulene i.e., cyclooctatetraene is non-aromatic.

What is monocyclic ring?

monocyclic. / (ˌmɒnəʊˈsaɪklɪk) / adjective. Also: mononuclear (of a chemical compound) containing only one ring of atoms. (of sepals, petals, or stamens) arranged in a single whorl.

Is naphthalene an annulene?

Napthalene. Naphthalene is a bicyclic aromatic hydrocarbon having a resonance stabilization energy per ring slightly less than that of benzene (36 kcal/mole). … One structure has two identifiable benzene rings and the other two are 10 π-electron annulenes.