What is busulfan used for?

Busulfan is used treat a certain type of chronic myelogenous leukemia (CML; a type of cancer of the white blood cells). Busulfan is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.

Is busulfan toxic?

Busulfan was the first cytotoxic drug reportedly associated with pulmonary toxicity [1]. The reported patterns of pulmonary toxicity include acute lung injury, chronic interstitial fibrosis, and alveolar hemorrhage.

Is busulfan still used?

Busulfan was the mainstay of the chemotherapeutic treatment of chronic myeloid leukemia (CML) until it was displaced by the new gold standard, imatinib, though it is still in use to a degree as a result of the drug’s relative low cost.

What is the notable side effect of busulfan?

There are side effects that commonly correlate with busulfan use and that are common among all alkylating agents. Common side effects associated with all alkylating agents include intestinal mucosal damage, alopecia, pancytopenia, anemia, amenorrhea, impaired spermatogenesis, and increased risk of malignancy.

Is chlorpromazine an antidepressant?

Chlorpromazine is a psychiatric medication that belongs to the class of drugs called phenothiazine antipsychotics. It works by helping to restore the balance of certain natural substances in the brain.

What are antimetabolite drugs?

Antimetabolites are a form of chemotherapy drug. They’re one of the most commonly used therapies to treat cancer. And they’re one of the oldest, dating back to the 1940s, when doctors used a medication that’s now considered an antimetabolite to treat children with leukemia.

Is busulfan chemotherapy?

IV busulfan is a chemotherapy agent, given to patients intravenously in combination with other drugs, commonly cyclophosphamide, or Fludara (fludarabine) or Clolar (clofarabine) before they have a stem cell transplant.

How do you administer busulfan?

Busulfan Injection is administered as a two-hour infusion every 6 hours over 4 consecutive days for a total of 16 doses prior to cyclophosphamide or melphalan and haematopoietic progenitor cell transplantation (HPCT).

What is the side effect of daunorubicin?

Cerubidine (daunorubicin) is a cancer (antineoplastic) medication used in the treatment of leukemia (blood cancer). Cerubidine is available in generic form. Common side effects of Cerubidine include nausea, vomiting, constipation, diarrhea, and loss of appetite. Cerubidine may cause urine to turn a reddish color.

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What kind of drug is hydroxycarbamide?

Hydroxycarbamide is one of a group of chemotherapy drugs known as anti metabolites. These drugs stop cells making and repairing DNA.

Who makes carmustine?

Production. Carmustine for injection was marketed under the name BiCNU by Bristol-Myers Squibb and now by Emcure Pharmaceuticals.

Is the metabolite of Busulphan?

Busulfan is used in hematopoietic stem cell transplants, but its system pharmacology has not been described. The busulfan metabolite EdAG irreversibly gluathionylates active site cysteines of glutaredoxins in vitro. Busulfan metabolism leads to inactivation of glutaredoxins via covalent modification by EdAG.

Does busulfan cause hair loss?

Hair loss. Hair loss is rare with low doses of busulfan. If you are having high-dose treatment with busulfan, all of the hair from your head will fall out. Your eyelashes, eyebrows and other body hair may also thin or fall out.

What are the adverse effects of methotrexate?

Methotrexate may cause side effects.Tell your doctor if any of these symptoms are severe or do not go away:

  • dizziness.
  • drowsiness.
  • headache.
  • swollen, tender gums.
  • decreased appetite.
  • reddened eyes.
  • hair loss.

What is the mechanism of action of busulfan?

Busulfan is a bifunctional alkylating agent. 3-5 Following systemic absorption, carbonium ions are rapidly formed, resulting in alkylation of DNA. This leads to breaks in the DNA molecule as well as cross-linking of the twin strands, resulting in interference of DNA replication and transcription of RNA.

What does chlorpromazine do to the brain?

Chlorpromazine exerts its antipsychotic effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of the brain, thereby preventing the excess of dopamine in the brain. This leads to a reduction in psychotic symptoms, such as hallucinations and delusions.

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Does chlorpromazine help anxiety?

Chlorpromazine is an antipsychotic medication that can be used to treat anxiety, mania, psychosis and schizophrenia. Injections: This is a short-acting injection containing 25mg in 1ml of injection. It is usually used in hospital when needed in an emergency.

Does chlorpromazine help you sleep?

The results showed that chlorpromazine given at bedtime coincided with a marked increase in actual sleep time as exemplified by a significant decrease in intermittent wakefulness. Total REM time was increased proportionately to the increase in actual sleep.

What is an alkylating drug?

What are Alkylating agents? Alkylating agents are compounds that work by adding an alkyl group to the guanine base of the DNA molecule, preventing the strands of the double helix from linking as they should. This causes breakage of the DNA strands, affecting the ability of the cancer cell to multiply.

Is doxorubicin an antimetabolite?

Anthracyclines are anti-tumor antibiotics that interfere with enzymes involved in copying DNA during the cell cycle. Examples of anthracyclines include: Daunorubicin. Doxorubicin (Adriamycin)

What is drug biotransformation?

Biotransformation is a metabolic process that takes place mainly in the liver and helps to facilitate the excretion of both exogenous and endogenous substances. A series of reactions alter the chemical structures of these substances.

What type of chemo is busulfan?

Drug type: Busulfan is an anti-cancer (antineoplastic or cytotoxic) chemotherapy drug. This medication is classified as an alkylating agent. (For more detail, see How this drug works section below).

How much does busulfan cost?

The cost for Busulfex intravenous solution (6 mg/mL) is around $4,186 for a supply of 80 milliliters, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

What does actinomycin D do?

Actinomycin D is a well-known antibiotic of the actinomycin group that exhibits high antibacterial and antitumor activity. Actinomycin D has been widely used in clinical practice since 1954 as an anticancer drug for treating many tumors and it is also a useful tool in biochemistry and molecular biology.

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What is the brand name of busulfan?

Myleran, Busulfex (busulfan) dosing, indications, interactions, adverse effects, and more.

Is busulfan a controlled substance?

Myleran is used in the treatment of bone marrow transplantation; chronic myelogenous leukemia and belongs to the drug class alkylating agents. There is positive evidence of human fetal risk during pregnancy. Myleran 2 mg is not a controlled substance under the Controlled Substances Act (CSA).

How do you dilute busulfan?

BUSULFEX must be diluted prior to intravenous infusion with either 0.9% Sodium Chloride Injection, USP (normal saline) or 5% Dextrose Injection, USP (D5W). The diluent quantity should be 10 times the volume of BUSULFEX, so that the final concentration of busulfan is approximately 0.5 mg per mL.

What is the difference between doxorubicin and daunorubicin?

Daunorubicin reached higher intracellular peak concentrations than doxorubicin, but the latter drug was retained much longer. The cell/plasma concentration ratio was higher for daunorubicin than for its reduced metabolite daunorubicinol. No doxorubicinol was found intracellularly.

What is the brand name for daunorubicin?

Daunorubicin is the generic name for the trade name drug Cerubidine.

Does daunorubicin cause hair loss?

Daunorubicin causes the urine to turn reddish in color, which may stain clothes. This is not blood. It is perfectly normal and lasts for only 1 or 2 days after each dose is given. This medicine often causes a temporary and total loss of hair.