What is CD117 positive?

Other mesenchymal tumors that were variably CD 117 positive included clear cell sarcoma (7 of 15), metastatic melanoma (9 of 25), and malignant fibrous histiocytoma (1 of 20). These results indicate that CD117 is a specific marker for GIST among tumors that occur in the GI tract and adjacent regions.

Does CD117 mean cancer?

Measuring the amount of CD117 in tumor tissue may help diagnose cancer and plan treatment. CD117 is a type of receptor tyrosine kinase and a type of tumor marker. Also called c-kit and stem cell factor receptor.

What does CD117 stain for?

Staining for CD117 occurs in a variety of tumor types, although strong staining is present mainly in mast cell disease and gastrointestinal stromal tumors, for which CD117 is the preferred marker. A minority of serous ovarian carcinomas stain strongly for CD117.

Is CD117 a kit?

CD117 (KIT) is a type III receptor tyrosine kinase operating in cell signal transduction in several cell types. Normally KIT is activated (phosphorylated) by binding of its ligand, the stem cell factor.

What does CD117 negative mean?

Staining for CD117 was considered negative if less than 5% of the tumor cells were weakly stained.

What is a GIST tumor?

A gastrointestinal stromal tumor (GIST) is a rare tumor in the digestive tract. Most GISTs start in the stomach or small intestine. But they can form anywhere along the digestive tract from the esophagus to the anus.

What is a CD117 marker?

CD117 (c-kit) is a transmembrane tyrosine kinase receptor that has been immunolocalized in various neoplasms, the most notable of which is gastrointestinal stromal tumors where c-kit is felt to be a relatively specific and sensitive immunohistochemical marker of gastrointestinal stromal tumors.

What is CD10 a marker for?

CD10 is a sensitive and diagnostically useful immunohistochemical marker of normal endometrial stroma and of endometrial stromal neoplasms.

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What is a CD34 cell?

CD34 is a 115-kDa transmembrane glycoprotein expressed on the surface of hematopoietic progenitor cells and small blood vessel endothelial cells. While the specific function of CD34 remains to be elucidated, it is regarded as a marker of hematopoietic stem cells (HSC) and hematopoietic progenitor cells.

Is mastocytosis fatal?

Mast cells build up in the skin, causing red or brown lesions that itch. By itself, cutaneous mastocytosis isn’t life-threatening. But people with the disorder have significant symptoms and have a much higher risk of a severe allergic reaction, which can be fatal.

Are mast cells CD117 positive?

Variable numbers of CD117 positive cells were seen in all leiomyomas. Tryptase immunostaining identified mast cells in 93.2% (41/44) of leiomyomas, and the number of mast cells per tumor decreased significantly from tumors of the upper esophagus to the esophageal-gastric junction (p<0.01).

What does tryptase measure?

The tryptase test is a useful indicator of mast cell activation. The tryptase test may be used: To confirm a diagnosis of anaphylaxis. Anaphylaxis is primarily diagnosed clinically, but a total tryptase may be ordered, along with a histamine test, to help confirm anaphylaxis as the cause of someone’s acute symptoms.

What is RET mutation?

Mutations in the RET gene are the most common genetic cause of Hirschsprung disease, a disorder that causes severe constipation or blockage of the intestine. More than 200 RET gene mutations are known to cause this condition.

What are the signs and symptoms of mastocytosis?

Signs and symptoms of systemic mastocytosis may include:

  • Flushing, itching or hives.
  • Abdominal pain, diarrhea, nausea or vomiting.
  • Anemia or bleeding disorders.
  • Bone and muscle pain.
  • Enlarged liver, spleen or lymph nodes.
  • Depression, mood changes or problems concentrating.

Is CKIT the same as CD117?

The CD117 gene, officially known as “KIT proto-oncogene receptor tyrosine kinase” (GenBank ID: 3815), is also more commonly known as c-kit, kit, or stem cell factor receptor. CD117 was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit.

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What is Carney’s triad?

Carney triad is a rare condition that describes the occurrence of three kinds of endocrine tumors in the same child. The tumors comprising the triad are tumors in the gastrointestinal tract (known as gastrointestinal stromal tumors, or GIST), pulmonary chondromas, and paragangliomas.

What is GATA3?

The GATA3 transcription factor is critical for the embryonic development of various tissues as well as for inflammatory and humoral immune responses and the proper functioning of the endothelium of blood vessels. GATA3 plays central role in allergy and immunity against worm infections.

What percentage of GIST tumors are cancerous?

Localized (cancer remains in the organ where it started): 93 percent.

Is GIST a rare disease?

GIST is extremely rare in children and adolescents, and the symptoms and pathology in these age groups are different from those in most adults. These cases generally present in the stomach, are more likely to show lymph node involvement, and are more likely to spread to the liver and abdominal lining.

Is GIST malignant or benign?

Gastrointestinal stromal tumors (GIST) account for 1% to 3% of all resected gastric tumors. They are mostly benign and are the commonest submucosal mass in the stomach. The preoperative characterization of malignancy is often difficult, and excision is the most common management option.

What are CD10 cells?

Identified in common acute lymphoblastic leukemia as a cancer specific antigen, CD10 is a cell surface ectoenzyme widely expressed on different types of cells. Earlier, it was used only as a cell surface marker to identify and differentiate between haematological malignancies.

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What cells are CD10 positive?

Among hematopoietic cells, CD10 expression is found in granulocytes and in B and T lymphocytes at particular stages of maturation. CD10 expression within the B-cell lineage has been very well characterized. Benign CD10+ B cells include B lymphoblasts as well as mature germinal center B cells (1, 18).

What CD10 means?

CD10: A cell surface enzyme with neutral metalloendopeptidase activity. CD10 is also known as CALLA (common acute lymphocytic leukemia antigen). It serves as a marker for the common form of ALL (acute lymphocytic leukemia) as well as for Burkitt lymphoma and follicular germinal center lymphoma.

What is CD in CD34?

CD34 derives its name from the cluster of differentiation protocol that identifies cell surface antigens.

What is a normal CD34 count?

Under normal conditions, CD34+ cells in PB range from 0.01 to 0.05%5; in the BM, the concentration is usually less than 1% of normal mononuclear cells.5, 6, 7, 8 The number of progenitor cells to be infused to reach a proper hematopoietic recovery is still controversial,9, 10 however a minimum of 2–5 × 106 CD34+ cells/ …

Are CD34 T cells?

Recent findings have shown that human multipotent progenitor/stem cells expressing CD34 have the capacity to differentiate into T cells when introduced into a thymic environment. … CD34+ thymocytes have no myeloid differentiation potential, but may include precursors for natural killer (NK) cells.