What is CLU gene?

What is CLU gene?

CLU (Clusterin) is a Protein Coding gene. Diseases associated with CLU include Follicular Dendritic Cell Sarcoma and Scrapie. Among its related pathways are Immune response Lectin induced complement pathway and Creation of C4 and C2 activators.

What does clusterin protein do?

Clusterin is ubiquitously expressed protein, with one isoform located in the nucleus and an 80 kDa secreted glycoprotein. Secreted clusterin is involved in lipid transport and is released in response to cell stress where it protects the cell by reducing oxidative stress and binding to misfolded proteins.

Where is clusterin produced?

CLU Gene Structure and Regulation. CLU is a single copy gene located at the p21-p12 locus on chromosome 8. CLU encodes nine exons and the majority of clusterin protein is produced from the CLU mRNA transcript NM_001831.3 (Prochnow et al., 2013).

What is the function of TREM2?

Normal Function The TREM2 gene provides instructions for making a protein called triggering receptor expressed on myeloid cells 2. As its name suggests, this protein is made in myeloid cells, which are cells produced in bone marrow.

Where is vitronectin found?

Vitronectin is a multifunctional adhesive glycoprotein found in the cir culation and different tissues.

Where is TREM2 found?

The TREM2 gene is located on human chromosome 6p21 and encodes a 230-amino acid glycoprotein [31]. The TREM2 gene is expressed in a subgroup of myeloid cells including dendritic cells, granulocytes, and tissue-specific macrophages like osteoclasts, Kuppfer cells and alveolar macrophages [32,33,34,35,36,37,38].

What does TREM2 stand for?

TREM2 (Triggering Receptor Expressed On Myeloid Cells 2) is a Protein Coding gene. Diseases associated with TREM2 include Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 2 and Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1.

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What is soluble TREM2?

Triggering receptor expressed on myeloid cells 2 (TREM2) is a microglial surface receptor genetically linked to the risk for Alzheimer’s disease (AD). A proteolytic product, soluble TREM2 (sTREM2), is abundant in the cerebrospinal fluid and its levels positively correlate with neuronal injury markers.

Is vitronectin a extracellular matrix?

Vitronectin (VN) is an extracellular matrix (ECM) protein, the synthesis of which in vivo by glioma cells correlates with tumor grade. … As well, the extent to which apoptosis could be inhibited was correlated with the levels of the Bcl-2 family of proteins that are known to modulate apoptosis and chemoresistance.

What is the vitronectin receptor?

The v3 vitronectin receptor is a member of the integrin superfamily of adhesion molecules. … It mediates cell adhesion to extracellular matrix by recognizing the conserved arg-gly-asp (RGD) sequence of several plasma and matrix proteins.

What is the cell that looks like a cross?

Laminin Fourteen other chain combinations have been identified in vivo. The trimeric proteins intersect to form a cross-like structure that can bind to other cell membrane and extracellular matrix molecules. … Laminin domains.

Laminin Domain II
Identifiers
InterPro IPR010307
showAvailable protein structures: