Gonadorelin is used to test how well the hypothalamus and the pituitary glands are working. It is also used to cause ovulation (release of an egg from the ovary) in women who do not have regular ovulation and menstrual periods because the hypothalamus gland does not release enough GnRH.
What is gonadorelin HCL?
Factrel (gonadorelin hydrochloride) is a synthetic form of gonadotropin-releasing hormone (GnRH) used to test how well the hypothalamus and pituitary glands are working. The brand name Factrel is discontinued, but generic versions may be available.
How long does it take for gonadorelin to work?
The usual dose of gonadorelin is 5 g every 90 minutes injected under the skin or into a vein by an infusion pump. The dose may be increased or decreased according to response and can range between 1 g and 20 g. This medication usually starts to work about 2 to 3 weeks after treatment is started.
How do you use gonadorelin?
Gonadorelin dosing information 0.1 mg injected once subcutaneously or intravenously as a single dose. Usual Adult Dose for Amenorrhea: 5 mcg every 90 minutes (range of 1 to 20 mcg) delivered intravenously by a pump over 1 minute, every ninety minutes for 21 days.
What does gonadorelin acetate do to men?
Gonadorelin helps increase sperm count in men as well as increased testosterone production. It also helps with testicular atrophy, or otherwise known as testicular shrinkage. Gonadorelin assists with sperm volume and sperm count as well.
Does gonadorelin cause weight gain?
Get medical help right away if you develop the following side effects: severe pain or swelling in the lower abdominal (pelvic) area, severe nausea/vomiting, diarrhea, sudden/rapid weight gain, difficulty breathing or decreased urination. Discuss the risks and benefits of this medication with your doctor.
Does gonadorelin increase sperm count?
Gonadorelin enhances semen production by increasing total expressible volume. Sperm quality was similar in gonadorelin-treated, untreated, and CPE-treated fish. The minimum effective gonadorelin dose for increasing semen volume is 60 g kg 1.
Can gonadorelin cause ED?
In women, the use of GnRH in the adjuvant treatment of breast cancer is associated with an increased rate of sexual dysfunction, but the symptoms are usually reversible on discontinuation of therapy.
Where should I inject gonadorelin?
Gonadorelin is injected into a vein or under the skin using an infusion pump, as directed by your doctor. If you are using this medication at home, learn all preparation and usage instructions from your health care professional and the medication package. Follow all instructions for using the infusion pump.
Do I have to refrigerate Gonadorelin?
Fertagyl is available in a concentration of 43 mcg/mL gonadorelin (as gonadorelin acetate) pH adjusted with sodium phosphate (monobasic and dibasic). Fertagyl is supplied in multi-dose vials containing 20 mL and 100 mL of sterile solution. STORAGE, HANDLING, AND DISPOSAL: Keep refrigerated: 2-8C (36-46F).
Does Gonadorelin raise estrogen?
Gonadorelin stimulates the pituitary gland in the brain to release the sex hormones luteinising hormone (LH) and follicle stimulating hormone (FSH). In women, FSH stimulates the production of oestrogen and the development of eggs in the ovaries.
How do you dilute Gonadorelin?
Preparation for single injection administration: Reconstitute 100 micrograms vial with 1.0 ml of sterile water for injections. Prepare solution immediately before use. After reconstitution, refrigerate and use within 1 day.
Does GnRH shrink fibroids?
Taking gonadotropin-releasing hormone analogue (GnRH-a) puts your body into a state like menopause for as long as you take it. This shrinks fibroids. After you stop taking it, your fibroids may grow back. Taking GnRH-a can cause serious side effects, such as bone loss.
How do you pronounce Gonadorelin?
Pronunciation : goe-nad-oh-RELL-in.
How is Gonadorelin made?
Gonadorelin is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pituitary.
How does hCG work in males?
How does hCG work? In men, hCG acts as an analog of LH, therefore stimulating the testicles to produce more testosterone. LH also stimulates production of sperm within the seminiferous tubules, which are structures inside the testicles, and therefore maintains fertility in men.
What are the side effects of GnRH injection?
Common side effects of the GnRH agonists and antagonists include symptoms of hypogonadism such as hot flashes, gynecomastia, fatigue, weight gain, fluid retention, erectile dysfunction and decreased libido. Long term therapy can result in metabolic abnormalities, weight gain, worsening of diabetes and osteoporosis.
How much does GnRH cost?
The current cost of one antagonist injection is 25,714 USD.
Is Gonadorelin a gonadotropin?
Gonadorelin is a medicine that is the same as gonadotropin-releasing hormone (GnRH) that is naturally released from the hypothalamus gland. GnRH causes the pituitary gland to release other hormones (luteinizing hormone [LH] and follicle-stimulating hormone [FSH]).
Can you get a girl pregnant while on testosterone?
Although more research is needed, we do know that it’s possible to get pregnant while taking testosterone. Whether you want to avoid pregnancy or are trying to conceive, we recommend you discuss your needs with your healthcare provider, and plan accordingly.
Can you take too much sermorelin?
Do not use more or less of it, and do not use it more often than your doctor ordered. The exact amount of medicine needed has been carefully worked out. Using too much will increase the risk of side effects, while using too little may not improve the condition.
Is Gonadorelin a peptide?
Gonadorelin is a ten-membered synthetic oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, glycyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It has a role as a gonadotropin releasing hormone agonist. It is an oligopeptide and a peptide hormone.
Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with Sun’Agri and INRAE in Avignon between 2019 and 2022. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. I love to write and share science related Stuff Here on my Website. I am currently continuing at Sun’Agri as an R&D engineer.