What is oxazolidinone used for?

Oxazolidinones are primarily used for the treatment of antimicrobial-resistant gram-positive bacterial infections caused by methicillin-resistant staphylococci, vancomycin-resistant enterococci and penicillin-resistant pneumococci. Linezolid is also used to treat multidrug-resistant Mycobacterium tuberculosis.

What is the structure of oxazolidinone?

Oxazolidinones are a class of compounds containing 2-oxazolidone in the structure. In chemistry, they are useful as Evans auxiliaries, which are used for chiral synthesis. Usually, the acid chloride substrate reacts with the oxazolidinone to form an imide.

What is oxazolidinone derivative?

Oxazolidinones are synthetic antibacterial agents with a distinctive mechanism of action having a wide spectrum of activity, oral bioavailability, and well-established structureactivity relationship (Jadhavar et al., 2015). From: Nontuberculous Mycobacteria (NTM), 2019.

Which drug belongs to the class of oxazolidinone?


Drug Drug Description
Tedizolid phosphate An oxazolidinone class antibiotic that inhibits bacterial protein synthesis and is proven to be effective in the treatment of certain Gram-positive bacterial infections.

What are the side effects of linezolid?

What Are Side Effects Associated with Using Linezolid?

  • diarrhea.
  • vomiting.
  • headache.
  • red blood cell deficiency.
  • low blood platelet count.
  • nausea.
  • abdominal pain.
  • loose stools.

Is linezolid safe to use?

When given for short periods, linezolid is a relatively safe antibiotic. It can be used in people of all ages and in people with liver disease or poor kidney function. Common side effects with short-term use include headache, diarrhea, rash, and nausea.

How do Lipopeptides work?

Lipopeptides exert their effect by binding and disrupting the cell membrane integrity of the target bacteria and initiating a series of events that eventually leads to cell death.

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Which is an aminoglycoside?

The aminoglycosides are broad-spectrum, bactericidal antibiotics that are commonly prescribed for children, primarily for infections caused by Gram-negative pathogens. The aminoglycosides include gentamicin, amikacin, tobramycin, neomycin, and streptomycin.

How do you pronounce oxazolidinone?

What is the mode of action of oxazolidinones?

The main action of oxazolidinones is by binding P site, inhibition of initiation complex and also translocation of peptidyl-tRNA from A site to P site (Fig. 1).

How does chloramphenicol work?

Chloramphenicol is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth.

What drugs are Lincosamides?

Lincosamides are a class of antibiotics, which include lincomycin, clindamycin, and pirlimycin.

What drug is a fluoroquinolone?

Fluoroquinolones are a class of antibiotics approved to treat or prevent certain bacterial infections. The fluoroquinolone antibiotics include ciprofloxacin (Cipro), gemifloxacin (Factive), levofloxacin (Levaquin), moxifloxacin (Avelox), and ofloxacin (Floxin).

What antibiotics are in the tetracycline family?

Tetracyclines (tetracycline, doxycycline, minocycline, tigecycline) are a class of medication used to manage and treat various bacterial infections. Tetracyclines classify as protein synthesis inhibitor antibiotics and are considered to be broad-spectrum.

Who discovered linezolid?

Linezolid was discovered by researchers at the Upjohn Company, in Kalamazoo, Michigan, as the result of a research program that extended over approximately 12 years.

What type of drug is linezolid?

Linezolid is a synthetic antibiotic belonging to a new class of antimicrobials called the oxazolidinones. Linezolid disrupts bacterial growth by inhibiting the initiation process of protein synthesis—a mechanism of action that is unique to this class of drugs.

Is linezolid a strong antibiotic?

Frequently asked questions about linezolid (Zyvox) Is linezolid (Zyvox) a strong antibiotic? Linezolid (Zyvox) is a prescription antibiotic that is used to treat various bacterial infections like skin infections, pneumonia, and infections that are resistant to other antibiotics.

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Is linezolid good for UTI?

In a cohort of patients with symptomatic VRE UTI, associated catheter use, and low acuity of illness, treatment with linezolid resulted in similar outcomes as comparator antibiotics. The findings suggest that linezolid is as effective as other VRE active antibiotics in the treatment of mild UTI caused by VRE.

What is linezolid tablet?

Linezolid is an antibiotic used to treat certain serious bacterial infections. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu).

Is linezolid an antidepressant?

Linezolid is an oxazolidinone antibiotic that is widely used in general hospitals. … Table 1.

Antidepressants Analgesics
Escitalopram Antituberculosis
SNRIs Isoniazid
Venlafaxine Anxiolytics
Duloxetine Buspirone

Can linezolid cause anemia?

Background: Linezolid has been associated with anemia and thrombocytopenia.

Is daptomycin a chemo drug?

Daptomycin | Journal of Antimicrobial Chemotherapy | Oxford Academic.

What drugs are lipopeptides?


Drug Target Type
Daptomycin P-glycoprotein 1 transporter
Polymyxin B Bacterial outer membrane target
Polymyxin B Solute carrier family 15 member 2 transporter
Caspofungin Solute carrier family 22 member 1 transporter

Is a lipopeptide a protein?

Lipopeptide detergents (LPDs) are composed of amphiphiles and two alkyl chains which are located on the last part of the peptide backbone. … Lipopeptide.

Cyclic lipopeptide antibiotics
OPM protein 1t5n

What are examples of quinolones?

Some examples of systemic quinolone antibiotics include:

  • ciprofloxacin (Cipro)
  • ciprofloxacin ER (Cipro XR)
  • levofloxacin (Levaquin)
  • moxifloxacin (Avelox)
  • gemifloxacin (Factive)
  • ofloxacin (generic tablet only)

Is ampicillin an aminoglycoside?

In the past, the aminoglycosides have been used in conjunction with beta-lactam antibiotics in streptococcal infections for their synergistic effects, in particular in endocarditis. One of the most frequent combinations is ampicillin (a beta-lactam, or penicillin-related antibiotic) and gentamicin.

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Is doxycycline an antibiotic?

Doxycycline is an antibiotic. It’s used to treat infections such as chest infections, skin infections, rosacea, dental infections and sexually transmitted infections (STIs), as well as a lot of other rare infections. It can also be used to prevent malaria if you’re travelling abroad.

How do you spell linezolid?

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