What is phenyl methyl pyrazolone?

Phenyl Methyl Pyrazolone (PMP) is a heterocyclic amine that i s used in hair colorants. The phenylhydrazine content in PMP is below the limit of detection. Phenyl Methyl Pyrazolone was slightly toxic to rats, with an oral LD,, of 3.5 g/kg.

What is the starting material for the synthesis of 3 Methyl 1 phenyl 5 Pyrazolone?

The 3-methyl-1-phenyl-1H-pyrazole-5(4H)-one (3a). This compound was synthesized according to the general procedure using 17 mmol (2.21 g) of ethyl acetoacetate and 14 mmol (1.51 g) of phenylhydrazine in 5 mL of glacial acetic acid by refluxing for 6 h.

Is pyrazole acidic or basic?

Pyrazole is a weak base, with pKb 11.5 (pKa of the conjugated acid 2.49 at 25 °C). Pyrazoles are also a class of compounds that have the ring C3N2 with adjacent nitrogen atoms.

How is pyrazole formed?

Pyrazole or isoxazole derivatives are prepared by a palladium-catalyzed four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide under ambient pressure, and an aryl iodide.

What are pyrazole derivatives?

Pyrazole derivatives play an important role in antitumor agents because of their good inhibitory activity against BRAF(V600E), EGFR, telomerase, ROS Receptor Tyrosine Kinase and Aurora-A kinase. In addition, pyrazole derivatives also show good antiinflammatory and anti-bacterial activities.

What is the molecular weight of 1/3 pyrazole?

222.026 4-iodo-1,3-dimethyl-1H-pyrazole

CAS Number 6647-97-8
Size 1g, 5g, 10g, 25g
Molecular Weight 222.026
Molecular Formula C5H7IN2
Purity 97%

Which are the applications of 1/3 pyrazole?

[3] Many pyrazole derivatives has already found their application as nonsteroidal anti-inflammatory drugs clinically, such as anti-pyrine or phenazone (analgesic and antipyretic), metamizole or dipyrone (analgesic and antipyretic), aminopyrine or aminophenazone (anti-inflammatory, antipyretic, and analgesic), …

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What is the another name of 1/3 pyrazole?

Synthesis of 1,3-substituted pyrazole (i.e. 1,3-diphenyl pyrazole) from diarylhydrazone (i.e. diphenyl hydrazone) and vicinal diol.

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