Tetrazole, which is usually used as the bioisoster of carboxylic acid, is metabolically stable to many of the biological transformations that the functionality of carboxylic acid is susceptible to in the liver .
What is tetrazole reaction?
Tetrazole based energetic materials produce high-temperature, non-toxic reaction products such as water and nitrogen gas, and have a high burn rate and relative stability, all of which are desirable properties. The delocalization energy in tetrazole is 209 kJ/mol.
Is tetrazole acidic or basic?
The acidic nature of tetrazole is similar to corresponding carboxylic acids, but there is a difference in annular tautomerism of ring tetrazoles to carboxylic acids. The acidic nature of tetrazole is mainly affected by substitution compound nature at C-5 position.
Are Tetrazoles basic?
It is a very weak base with a pKa of –3.0 and protonation occurs at the C4-position. There is weak absorption in the UV spectrum of 5-substituted tetrazole in ethanol around 200–220 nm. H NMR (D2O), δ (ppm): C5H, 9.5. C NMR (DMSO-d6), δ (ppm): C5, 143.9.
What is a pyrrole ring?
Pyrrole, any of a class of organic compounds of the heterocyclic series characterized by a ring structure composed of four carbon atoms and one nitrogen atom. … In heme and chlorophyll, four pyrrole rings are joined in a larger ring system known as porphyrin.
What is a triazole ring?
A triazole refers to any of the heterocyclic compounds with molecular formula C2H3N3, having a five-membered ring of two carbon atoms and three nitrogen atoms. … Each of these has two tautomers that differ by which nitrogen has a hydrogen bonded to it.
Is Tetrazole soluble in water?
Soluble in water (23 g/100 mL at 20°C) Reacts slowly with water (moisture) with release of corrosive gases (ammonia, nitrogen oxides). Soluble in water. Soluble in acetonitrile.
What is the nature of aniline?
Aniline is an organic compound with the formula C6H5NH2. Consisting of a phenyl group attached to an amino group, aniline is the simplest aromatic amine.
Are tetrazoles lipophilic?
However, the tetrazole group often exhibits a prolonged half-life because of the enhanced metabolic stability,39 , 40 enhanced spatial delocalization of the negative charge, and better membrane penetration resulting from increased lipophilicity (tetrazoles with a mobile H are ionized at physiological pH (∼7.4), but are …
Is triazole basic?
1,2,3-Triazole is one of a pair of isomeric chemical compounds with molecular formula C2H3N3, called triazoles, which have a five-membered ring of two carbon atoms and three nitrogen atoms. 1,2,3-Triazole is a basic aromatic heterocycle.
How do you make Azidoazide azide?
How do you synthesize Tetrazoles?
An organocatalyst, 5-azido-1-methyl-3,4-dihydro-2H-pyrrolium azide, generated in situ from N-methyl-2-pyrrolidone (NMP), sodium azide, and trimethylsilyl chloride, enables the formation of tetrazoles by cycloaddition of sodium azide with organic nitriles under neutral conditions and microwave heating.
What is porphyrin ring?
A porphyrin is a large ring molecule consisting of 4 pyrroles, which are smaller rings made from 4 carbons and 1 nitrogen. These pyrrole molecules are connected together through a series of single and double bonds which forms the molecule into a large ring. … The model of a general porphyrin is called porphin.
What causes pyrrole disorder?
The Cause Of Pyrrole Disorder Pyrrole disorder is caused by the overproduction of hydroxyhempyrolin (HPL). The HPL binds zinc and B6 preventing their use by the body and causing excretion in the urine and hair. HPL is a biomarker for oxidative stress and is neurotoxic.
What is an example of pyrrole?
Pyrrole is a heterocyclic aromatic organic compound, a five-membered ring with the formula C4H4NH. … Substituted derivatives are also called pyrroles, e.g., N-methylpyrrole, C4H4NCH3. Porphobilinogen, a trisubstituted pyrrole, is the biosynthetic precursor to many natural products such as heme.
Is fluconazole a triazole?
Fluconazole is a new triazole antifungal agent with unique pharmacokinetic properties. It can be administered orally or parenterally and achieves rapid distribution by either route, and its absorption is not affected by the presence of food.
Is ketoconazole a triazole?
Triazole antifungals: fluconazole, itraconazole, posaconazole, voriconazole. Imidazole antifungals: clotrimazole, econazole, miconazole, ketoconazole and tioconazole. Polyene antifungals: amphotericin, nystatin.
Which of the following contain triazole ring?
For example, antifungal drugs containing the triazole ring include the following: (1) itraconazole, (2) fluconazole, (3) voriconazole, (4)  the anti-viral drug ribavirin, and (5) mubritinib (used for breast, bladder, kidney, and prostate cancers) (Fig. 1).
What is the molecular structure of aniline?
C6H5NH2 Aniline / Formula Aniline is also known as aminobenzene or phenyl amine; has a chemical formula of C6H7N or C6H5NH2; and has 6 carbon (C) atoms, 7 hydrogen (H) atoms, and 1 nitrogen (N) atom. It is an oily, flammable liquid with a pungent smell. It is slightly soluble in water.
What is the pH of aniline?
7.818 Hence, the pH of the solution is 7.818. The ionization constant of the conjugate acid of aniline is calculated by dividing the ionic product of water by the ionization constant of aniline.
Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with Sun’Agri and INRAE in Avignon between 2019 and 2022. My thesis aimed to study dynamic agrivoltaic systems, in my case in arboriculture. I love to write and share science related Stuff Here on my Website. I am currently continuing at Sun’Agri as an R&D engineer.