What is the ligand for CCR7?

CCL19 and CCL21 are the sole ligands for the CC-chemokine receptor 7 (CCR7), which is expressed by various subsets of immune cells1.

What is the function of CCR7?

CCR7 was described initially as a potent leukocyte chemotactic receptor that was later shown to be responsible of directing the migration of dendritic cells (DCs) to the lymph nodes where these cells play an important role in the initiation of the immune response.

Is CCR7 on T cells?

In humans, CCR7 has been described as a defining factor for two different types of memory T cells, termed central and effector memory T cells (7). Central memory cells express CCR7 and represent a nonpolarized Ag-experienced cell population that lacks immediate effector cell functions.

Where is CCR7 produced?

Cell Biology of the B Cell Receptor B-cell migration is supported by the upregulation of CCR7 (CC chemokine receptor 7) that senses CCL19 and CCL21 (CC chemokine ligands 19 and 21) produced by stromal cells in the T-cell zone (Reif et al., 2002).

What does CCR7 stand for?

Acronym. Definition. CCR7. C-C Chemokine Receptor 7 (gene)

Do B cells express CCR7?

Naive B cells also express CCR7, though in lower amounts than on T cells, and they use this receptor along with CXCR4 and CXCR5, to enter lymphoid tissues from the blood (22, 23).

What are CCL19 CCL21 and CCR7?

Abstract. The chemokine receptor CCR7 and its ligands CCL19 and CCL21 control a diverse array of migratory events in adaptive immune function. Most prominently, CCR7 promotes homing of T cells and DCs to T cell areas of lymphoid tissues where T cell priming occurs.

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Where is CCR5 found?

C-C chemokine receptor type 5, also known as CCR5 or CD195, is a protein on the surface of white blood cells that is involved in the immune system as it acts as a receptor for chemokines. In humans, the CCR5 gene that encodes the CCR5 protein is located on the short (p) arm at position 21 on chromosome 3.

Is CCR7 intracellular?

Chemokine receptor CCR7 induces intracellular signaling that inhibits apoptosis of mature dendritic cells. Blood.

Why is the chemokine receptor CCR7 on DCs important?

CCR7 is necessary to direct dendritic cells (DCs) to secondary lymphoid nodes and to elicit an adaptative immune response. … In addition to chemotaxis, CCR7 regulates the migratory speed of DCs. We investigated the intracellular pathways that regulate CCR7-dependent chemotaxis and migratory speed.

What does CCL19 and CCL21 do?

Our findings indicate that CCL19 and CCL21 are potent natural adjuvants for terminal activation of DCs and suggest that chemokines not only orchestrate DC migration but also regulate their immunogenic potential for the induction of T cell responses.

What is CD45RO?

CD45RO enhances both T cell receptor and B cell receptor signaling mediated activation.

What produces CCR7?

This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. CCR7 has been shown to stimulate dendritic cell maturation.

Which receptors are related to CD28?

A counter-receptor for CD28 is the B7 molecule expressed on activated B cells, dendritic cells, and macrophages. B7 also binds to CTLA-4, a receptor that is structurally related to CD28.

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Where is CXCL13 found?

CXCL13 is elevated in serum of prostate cancer patients and was found to be a better predictor of prostate cancer than prostate-specific antigen (PSA). Also, CXCL13 is highly expressed in human bone marrow endothelial cells and osteoblasts, but not in osteoclasts, in response to IL-6 treatment.


Chemokines are small proteins with a molecular mass of 6–14 kDa that induce chemotaxis by binding to G-protein-coupled receptors (GPCRs) on the cell surface [1], [2]. … It has been reported that CCR8 is the predominant chemokine receptor expressed in T helper type 2 (Th2) cells [10], [11].

What does CCR4 bind to?

The chemokine receptor CCR4 has at least two natural agonist ligands, MDC (CCL22) and TARC (CCL17) which bind to the same orthosteric site with a similar affinity.

What is the difference between central memory T cells and effector memory T cells?

One possibility is that effector memory cells present an immediate, but not sustained, defense at pathogen sites of entry, whereas central memory T cells sustain the response by proliferating in the secondary lymphoid organs and producing a supply of new effectors (21–23).

Where are CCL19 and CCL21 displayed?

CCR7 and CCR5 and immune anatomy CCL19 and CCL21 are expressed on high endothelial venules and in the T-cell zones in lymph nodes and other secondary lymphoid organs, and these chemokines are required for trafficking and positioning of T cells and DCs within secondary lymphoid organs.

Is CCR5 good or bad?

Individuals who are naturally homozygous for the delta32 mutation, which abolishes CCR5 expression, are generally healthy and at no apparent disadvantage. However, apart from the protective effects against HIV infection, the impacts of this mutation, positive or negative, on other diseases are open to debate.

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Is CCR5 bad?

CCR5-Δ32 is also, after all, one of the most studied mutations. He’s work immediately provoked outrage among scientists, who knew enough to know how much they did not know about the risks of altering CCR5. And now a new study suggests that CCR5-Δ32 is indeed harmful overall.

Is CCR7 a chemokine?

Introduction. The CCR7 receptor, a member of the C-C chemokine receptor family, is a G protein-coupled receptor (GPCR). It was identified as a gene induced by the Epstein-Barr virus (EBV). CCR7 is expressed in various lymphoid tissues including B and T lymphocytes and mature dendritic cells (DC).