Call-Exner bodies, thought to represent an attempt by neoplastic cells to form basement membrane, are seen most frequently in granulosa cell tumors, but are occasionally reported in testicular tumors that contain epithelial elements of sex-cord origin.

What is a Brenner tumor?

Brenner tumor of the ovary is a solid, abnormal growth (tumor) on the ovary. Most Brenner tumors are not cancerous (benign). About 5% of Brenner tumors are cancerous (malignant) or have a small chance of spreading beyond its original location (borderline). These tumors most often occur in women after menopause.

What is Dysgerminoma of the ovary?

(DIS-jer-mih-NOH-muh) A type of cancer that begins in germ cells in females. Germ cells are cells that form sperm in males or eggs in females. Dysgerminomas occur most often in the ovaries, but they may also occur in other areas of the body, including the central nervous system.

What is a granulosa cell tumor?

Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. This type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman’s body.

Which is the most radiosensitive ovarian tumor?

The TOV21G and CAOV4 lines showed the highest levels of radiation sensitivity, while HEY, and OVCA420 were the most radioresistant from the panel tested. Curiously, the control cell line IOSE29, derived from normal ovarian tissue, is intermediate in the range of radiosensitivities measured (Fig. 1).

What is Sertoli cell tumor?

Specialty. Oncology. A Sertoli cell tumour, also Sertoli cell tumor (US spelling), is a sex cord-gonadal stromal tumor of Sertoli cells. They can occur in the testis or ovary. They are very rare and generally peak between the ages of 35 and 50.

What is embryonal carcinoma?

Embryonal carcinoma is a type of testicular cancer, which is cancer that starts in the testicles, the male reproductive glands located in the scrotum. It most often develops in young and middle-aged men. It tends to grow rapidly and spread outside the testicle.

What is a Chondroblastoma?

A chondroblastoma is a rare type of noncancerous bone tumor that begins in cartilage. This is the tough, rubbery connective tissue from which most bones develop. It plays an important role in the growth process. There are many different types of cartilage in the body.

What is Meigs?

In medicine, Meigs’s syndrome, also Meigs syndrome or DemonsMeigs syndrome, is the triad of ascites, pleural effusion, and benign ovarian tumor (ovarian fibroma, fibrothecoma, Brenner tumour, and occasionally granulosa cell tumour). Meigs syndrome resolves after the resection of the tumor.

Is seminoma a germ cell tumor?

Two of the most common germ cell tumors are seminoma and nonseminoma. Seminomas make up about half of all germ cell tumors. They usually grow slowly. Our doctors can often cure early-stage seminomas because they’re less likely to metastasize (spread) to other parts of the body.

Can dysgerminoma be benign?

Dysgerminoma: This is the most common type of malignant ovarian germ cell tumor. Mature teratoma (dermoid cyst or ovarian cyst): This is the most common type of benign ovarian germ cell tumor. These noncancerous tumors usually grow in teenage girls and young women.

Is dysgerminoma benign or malignant?

A dysgerminoma is a type of germ cell tumor; it usually is malignant and usually occurs in the ovary. A tumor of the identical histology but not occurring in the ovary may be described by an alternate name: seminoma in the testis or germinoma in the central nervous system or other parts of the body.

What are the symptoms of granulosa cell Tumour?

The clinical symptoms of GCT are abdominal pain and abnormal vaginal bleeding, and some cases may also present with menorrhagia, irregular menstruation, or amenorrhea in the reproductive age group. GCT is a cancer with long natural history, and recurrence often happens after 5 years of follow-up [1].

Where are granulosa cells located?

primordial ovarian follicle Granulosa cells form a single layer around the OOCYTE in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the OVUM in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors (RECEPTORS, LH).

Are granular cell tumors cancerous?

It may also occur in the chest, breast, esophagus, stomach, or other internal organ. Most granular cell tumors are benign (not cancer), but some may be malignant (cancer) and spread quickly to nearby tissue. They usually occur in middle-aged adults. Also called Abrikossoff tumor.

What is an ovarian tumor called?

The mature teratoma is by far the most common ovarian germ cell tumor. It is a benign tumor that usually affects women of reproductive age (teens through forties). It is often called a dermoid cyst because its lining is made up of tissue similar to skin (dermis).

Are Dysgerminoma radiosensitive?

Ovarian dysgerminoma is a highly radiosensitive malignant tumor occurring in young age group. The conventional treatment was total abdominal hysterectomy and bilateral salpingo-oophorectomy followed by radiotherapy.

What is function of Sertoli cells?

Sertoli cells are the somatic cells of the testis that are essential for testis formation and spermatogenesis. Sertoli cells facilitate the progression of germ cells to spermatozoa via direct contact and by controlling the environment milieu within the seminiferous tubules.

What is Sertoli-Leydig tumor?

Sertoli-Leydig cell tumor (SLCT) is a rare cancer of the ovaries. The cancer cells produce and release a male sex hormone called testosterone.

What do Sertoli cells secrete?

Sertoli cells produce and secrete the peptide hormone inhibin B into the circulation as a response to FSH stimulation.

What are the worst cancers?

Top 5 Deadliest Cancers

What is it called when you remove your balls?

An orchiectomy is surgery done to remove one or both of your testicles.

What is the most aggressive testicular tumor?

Nonseminomatous Germ Cell Tumors Embryonal carcinoma: present in about 40 percent of tumors and among the most rapidly growing and potentially aggressive tumor types. Embryonal carcinoma can secrete HCG or alpha fetoprotein (AFP).

What is a osteochondroma?

Listen to pronunciation. (OS-tee-oh-kon-DROH-muh) A benign (not cancer) tumor that has both bone and cartilage in it. This type of tumor usually occurs at the ends of the long bones of the arms and legs or in the pelvis or shoulder.

What is an Adamantinoma?

Adamantinoma is a rare bone cancer. Most of the time, adamantinoma grows in the lower leg. It often starts as a lump in the middle of the shinbone (tibia) or the calf bone (fibula). Adamantinoma can also occur in the jaw bone (mandible) or, sometimes, the forearm, hands, or feet.

Is chondroblastoma bad?

Chondroblastomas are benign lesions but can be locally aggressive and rarely even metastatic disease has been documented.

Is Meigs syndrome cancerous?

Meigs syndrome is an uncommon presentation, where a benign ovarian tumor present along with ascites and pleural effusion. About 1% of ovarian tumors can present as Meigs syndrome. A similar presentation can be seen in many metastatic malignancies.

Who was Meigs named after?

Meigs’ syndrome is defined as presence of ascites with hydrothorax in association with benign ovarian tumor. The syndrome is named after Joe Vincent Meigs (1892-1963), a Harvard Medical School Professor of Gynecology.

What is cause for Meigs syndrome?

Meigs’ syndrome is diagnosed based on a triad of an ovarian fibroma, pleural effusion and ascites. It resolves spontaneously after the resection of the fibroma. In 1852, Blin published the description of an ovarian fibroma with abdominal effusion in the Socit de Biology de Paris (cited by Lallemand).