Why is demeclocycline used for SIADH?

Demeclocycline has been used in treatment of the syndrome of inappropriate antidiuretic hormone (ADH) secretion (SIADH), as it acts on collecting tubule cells to diminish their responsiveness to ADH, in effect essentially inducing nephrogenic diabetes insipidus.

Why is demeclocycline banned?

However, demeclocycline is not approved by the US Food and Drug Administration (FDA) or the European Medicines Agency (EMA) to treat hyponatremia, and can cause nephrotoxicity in patients with heart failure and cirrhosis, although this is usually reversible (Singer and Rotenberg, 1973).

When do you take demeclocycline?

Demeclocycline is a tetracycline antibiotic that is used to treat many different bacterial infections, such as urinary tract infections, lung infections, intestinal infections, acne, gonorrhea, chlamydia, Rocky Mountain spotted fever, and others.

What is the mechanism of action of demeclocycline?

Mechanism of action As with related tetracycline antibiotics, demeclocycline acts by binding to the 30S ribosomal subunit to inhibit binding of aminoacyl tRNA which impairs protein synthesis by bacteria. It is bacteriostatic (it impairs bacterial growth, but does not kill bacteria directly).

What is Demeclocycline prescribed for?

DEMECLOCYCLINE (dem e kloe SYE kleen) is a tetracycline antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.

Is Demeclocycline ADH an antagonist?

Demeclocycline is not a direct antagonist of the vasopressin receptors however, but rather inhibits activation of the intracellular second messenger cascade of this receptor in the kidney by an unknown mechanism.

Which tetracycline causes diabetes insipidus?

Demeclocycline is a tetracycline derivative that induces diabetes insipidus by impairing the generation and action of cAMP, thus interfering with the action of AVP on the collecting duct.

What are the two most significant adverse reaction of aminoglycosides?

The major side effects of aminoglycosides are kidney injury, hearing impairment and vestibular toxicity.

Is Demeclocycline a Vaptan?

Pharmacological therapy generally comprises a vaptan (specific vasopressin2 receptor antagonists) or demeclocycline in some countries (e.g. France and the UK); other options may include urea or loop diuretics or combinations of above treatments 16.

How do you take demeclocycline?

Demeclocycline comes as a tablet to take by mouth. It usually is taken two or four times a day. Drink a full glass of water with each dose. Take demeclocycline on an empty stomach at least 1 hour before or 2 hours after meals.

What is another name for demeclocycline?

BRAND NAME(S): Declomycin. USES: Demeclocycline is used to treat a wide variety of bacterial infections, including those that cause acne. This medication is known as a tetracycline antibiotic. It works by stopping the growth of bacteria.

How do you take declomycin?

Take this medication by mouth, usually 2 to 4 times a day or as directed by your doctor. Demeclocycline works best when taken on an empty stomach at least 1 hour before or 2 hours after a meal. Take each dose with a full glass of water (8 ounces or 240 milliliters) unless your doctor directs you otherwise.

What is the mechanism of action of tolvaptan?

Mechanism of action and uses Tolvaptan is a competitive antagonist at vasopressin V2 receptors. Its major action is in the renal collecting ducts to reduce water reabsorption and produce aquaresis without sodium loss, thus increasing free water clearance and correcting dilutional hyponatraemia.

What is the mechanism of action of desmopressin?

By mimicking the actions of endogenous ADH, desmopressin acts as a selective agonist of V2 receptors expressed in the renal collecting duct (CD) to increase water re-absorption and reduce urine production.

What do Vaptans do?

The vaptans constitute a new class of pharmaceuticals developed for the treatment of the hypervolemic and euvolemic forms of hyponatremia. These agents are nonpeptide vasopressin antagonists that interfere with the antidiuretic effect of the hormone by competitively binding to V(2) receptors in the kidney.

What are the side effects of doxycycline?


What causes SIADH?

Things that cause SIADH include infections, asthma, brain inflammation, certain medications, hereditary factors and other factors. SIADH is the syndrome of inappropriate antidiuretic hormone secretion.

What is SIADH and how is it treated?

The most commonly prescribed treatment for SIADH is fluid and water restriction. If the condition is chronic, fluid restriction may need to be permanent. Treatment may also include: Certain medications that inhibit the action of ADH (also called vasopressin)

What medications inhibit ADH?

Vasopressin receptor antagonists (Vaptans) are a new group of nonpeptide drugs which have been used in various clinical conditions with limited success. Whereas conivaptan is to be administered intravenously, the other vaptans like tolvaptan, lixivaptan, and satavaptan are effective as oral medication.

What does ADH antagonist do?

Tolvaptan is a vasopressin receptor antagonist. Vasopressin (a.k.a. ADH or antidiuretic hormone) helps to regulate water retention by absorbing water in the collecting ducts of the nephron. Blocking this receptor will allow water to be excreted more readily.

What does vasopressin receptor antagonist do?

Vasopressin antagonists are drugs that bind to vasopressin receptors (V1A, V1B and V2) and block the action of vasopressin (antidiuretic hormone, ADH), which is a hormone released by the pituitary gland. Vasopressin causes vasoconstriction and increases reabsorption of water by the kidneys.

What medications increase risk of diabetes insipidus?

Causes of nephrogenic diabetes insipidus in adults include:

What is Siads?

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a condition in which the body makes too much antidiuretic hormone (ADH). This hormone helps the kidneys control the amount of water your body loses through the urine. SIADH causes the body to retain too much water.

Which of these tetracyclines is used in the treatment of hyponatremia due to SIADH?

Demeclocycline (dem e kloe sye’ kleen) is a tetracycline antibiotic that is used for therapy of mild-to-moderate infections due to susceptible organisms. It is also used off-label as therapy of hyponatremia and SIADH.

Which conditions are serious adverse effects of aminoglycosides?

Serious side effects of aminoglycosides include:

Which of the following is among the most serious adverse effects of aminoglycoside antibiotics when given for prolonged durations?

One of the most concerning side effects of aminoglycoside is kidney toxicity.

Which conditions are serious adverse effects of aminoglycosides select all that apply?

Use of aminoglycosides may result to these adverse effects: CNS: ototoxicity, irreversible deafness, vestibular paralysis, confusion, depression, disorientation, numbness, tingling, weakness. Renal: renal failure.

What is the difference between vasopressin and desmopressin?

Desmopressin (1-deamino-8-O-arginine-vasopressin, DDAVP) is a synthetic analogue of arginine vasopressin. It has 10 times the antidiuretic action of vasopressin, but 1500 times less vasoconstrictor action.

Which drug is a selective vasopressin V2 receptor agonist?

Tolvaptan (Samsca) is an oral V2 receptor antagonist and has been approved by the US Food and Drug Administration (FDA) for use in patients with CHF or cirrhosis and hyponatremia, and is also used in patients with SIADH. Conivaptan (Vaprisol) is also approved by the US FDA for treatment of euvolemic hyponatremia.

What’s the definition of vasopressin?

: a polypeptide hormone secreted by the posterior lobe of the pituitary gland or obtained synthetically that increases blood pressure and decreases urine flow.