What is imipramine pamoate used for?

This medication is used to treat depression. Using this medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily life. Imipramine pamoate belongs to a class of medications called tricyclic antidepressants. What is the difference between Imipramine HCL and pamoate?
The pamoate is much more expensive than hydrochloride but the pamoate says that it’s “PM” as in “Tofranil-PM”, while the hydrochloride is just “Tofranil”. Is the pamoate actually more sedating, or is this some sort of marketing thing?

What does imipramine do to the brain?

Imipramine works by inhibiting the reuptake of certain neurotransmitters in the brain, including acetylcholine, dopamine, norepinephrine, and serotonin. It also acts on certain other receptors, such as H₁ receptors for histamine. Does imipramine make you sleepy?
Take imipramine exactly as your doctor tells you to. It can cause drowsiness so your doctor may advise you to take a small dose to begin with, and then that you gradually increase it as your body becomes used to the medicine.

What is the brand name for desipramine?

Desipramine is available as a brand-name drug called Norpramin. It’s also available as a generic drug. What is Tofranil PM used for?

This medication is used to treat depression. Using this medication may improve your mood, sleep, appetite, and energy level and may help restore your interest in daily life. Imipramine pamoate belongs to a class of medications called tricyclic antidepressants.

Frequently Asked Questions(FAQ)

Is imipramine an anticholinergic?

Imipramine, and its metabolite desipramine, have no appreciable affinity for the dopamine transporter (K_i = 8,500 and >10,000 nM, respectively). Acetylcholine: imipramine is an anticholinergic, specifically an antagonist of the muscarinic acetylcholine receptors.

What is the mechanism of action of imipramine?

Imipramine is a tricyclic antidepressant that has been used since the 1950s. Its primary mechanism of action is to inhibit the reuptake of serotonin and norepinephrine, thus elevating the levels of these neurotransmitters in the brain.

Who should not take imipramine?

You should not breastfeed while using imipramine. Do not give this medicine to a child without medical advice. Imipramine is not approved to treat depression in anyone younger than 18 years old. Imipramine should not be used to treat bed-wetting in a child younger than 6 years old.

Is imipramine used to treat IBS?

Tricyclic agents such as amitriptyline and imipramine were initially prescribed to IBS patients with significant depression. Today, they are frequently used to treat patients with severe or refractory IBS symptoms and may have analgesic and neuromodulatory benefits in addition to their psychotropic effects.

Is constipation a side effect of imipramine?

Does imipramine cause hair loss?

Thirteen patients were enrolled in a double-blind, placebo-controlled study of efficacy of imipramine in alopecia. After six months clinically significant hair regrowth occurred in 5 of the 7 patients on imipramine, whereas no response was observed in the placebo group.

Is imipramine good for anxiety?

Physicians use tricyclic antidepressants in the treatment of panic disorder, PTSD, generalized anxiety and depression that occurs with anxiety. Of this family, imipramine has been the focus of most of the panic treatment research.

Does imipramine cause memory loss?

For both depressed and nondepressed subjects, the effect of imipramine on cognition was minimal. A subtle decrement in general cognitive function was evident in those treated with imipramine, as compared with those treated with placebo. No effects were observed on memory.

Do tricyclic antidepressants help anxiety?

Tricyclic antidepressants are used primarily to treat mood disorders but also have their place in the treatment of anxiety disorders, personality disorders, and neurological disorders. 2 They are often used when other drugs are unable to provide relief. Mood disorders often treated with TCAs include: Bipolar disorder.

Is tolbutamide still used?

Tolbutamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolbutamide is in a class of medications called sulfonylureas.

Is chlorpromazine an antidepressant?

Chlorpromazine is a psychiatric medication that belongs to the class of drugs called phenothiazine antipsychotics. It works by helping to restore the balance of certain natural substances in the brain.

What time of day should I take desipramine?

Therefore, depending on how this medication affects you, your doctor may direct you to take the entire dose once daily either in the morning or at bedtime. Follow your doctor’s instructions carefully. Do not take more or less medication or take it more frequently than prescribed.

Is desipramine a sedative?

Desipramine tends to be less sedating than other TCAs and tends to produce fewer anticholinergic effects such as dry mouth, constipation, urinary retention, blurred vision, and cognitive or memory impairments.

Does desipramine increase blood pressure?

Desipramine treatment was associated with significant increases in pulse, reclining systolic and diastolic blood pressures, and orthostatic hypotension. These effects were clearly evident in the first week of treatment and remained relatively unchanged during the subsequent 5 weeks.

What does desmopressin treat?

Desmopressin is used to control the symptoms of a certain type of diabetes insipidus (‘water diabetes’; condition in which the body produces an abnormally large amount of urine).

What is Tofranil tab?

Tofranil is a tricyclic antidepressant used to treat symptoms of depression. This medicine is sometimes used to treat bed-wetting in children ages 6 and older. Tofranil may also be used for purposes not listed in this medication guide.

Is imipramine a SNRI?

Animals in a drug treatment group received one of four drugs (all at 10 mg/kg in 10 ml vehicle, once per day): venlafaxine (an SNRI), imipramine, a tricyclic which inhibits reuptake of serotonin and norepinephrine, maprotiline, a norepinephrine reuptake inhibitor (NRI), or fluoxetine (an SSRI).

Is Buspar anticholinergic?

Vistaril and Buspar belong to different drug classes. Vistaril is an antihistamine with anticholinergic (drying) and sedative properties and Buspar is an antianxiety agent.

Is loratadine an anticholinergic?

One of these studies9 gave loratadine 2 points on the Anticholinergic Risk Scale, indicating that it entails intermediate risk; another study8 gave loratadine 0 points, which means that it has no known anticholinergic properties.

How old is doxepin?

Doxepin, which was approved as an antidepressant in 1969, for many years has been prescribed at low to moderate doses specifically to help with insomnia complaints. The pill strengths range from 10 to 150 mg, with the prescribing guidelines going as high as 300 mg daily doses for depression.

Which is best amitriptyline or imipramine?

The clinical lore that imipramine is more effective for retarded depression and amitriptyline for anxious, agitated depression was not supported by this study. Of special interest is the fact that the imipramine pamoate group had significantly earlier rising times, and a trend toward better quality of sleep.

What is the difference between imipramine and amitriptyline?

Elavil (amitriptyline) regulates mood and treats nerve pain, but has more side effects than alternatives. Improves your mood and stops bedwetting in children. Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.